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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1C All Species: 15.15
Human Site: S18 Identified Species: 47.62
UniProt: Q13936 Number Species: 7
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13936 NP_000710.5 2221 248892 S18 P E E N H Q G S N Y G S P R P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001117926 2225 248451 S60 P G Q L T S G S N Y G S P R P
Dog Lupus familis XP_534932 2114 236979 G18 P E H I P T P G A A L S W Q A
Cat Felis silvestris
Mouse Mus musculus Q01815 2139 240120 S18 P E E N H Q G S N Y G S P R P
Rat Rattus norvegicus P22002 2169 243464 S48 F Y I S P G G S N Y G S P R P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 S20 P E E A N Y A S S T R I P L P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_571975 2168 243196 H18 P E D T L E N H Q G S N Y S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24270 2516 276682 S44 A E T P T R G S R K Y N R K S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 94 90.9 N.A. 91.2 90.5 N.A. N.A. 66.4 N.A. 76.5 N.A. 44.4 N.A. N.A. N.A.
Protein Similarity: 100 N.A. 95.3 92.2 N.A. 92.9 92.4 N.A. N.A. 76.6 N.A. 84.1 N.A. 57.2 N.A. N.A. N.A.
P-Site Identity: 100 N.A. 66.6 20 N.A. 100 60 N.A. N.A. 40 N.A. 13.3 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 N.A. 73.3 26.6 N.A. 100 66.6 N.A. N.A. 53.3 N.A. 33.3 N.A. 40 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 0 13 0 0 13 0 13 13 0 0 0 0 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 75 38 0 0 13 0 0 0 0 0 0 0 0 0 % E
% Phe: 13 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 13 0 0 0 13 63 13 0 13 50 0 0 0 0 % G
% His: 0 0 13 0 25 0 0 13 0 0 0 0 0 0 0 % H
% Ile: 0 0 13 13 0 0 0 0 0 0 0 13 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 13 0 0 0 13 0 % K
% Leu: 0 0 0 13 13 0 0 0 0 0 13 0 0 13 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 25 13 0 13 0 50 0 0 25 0 0 0 % N
% Pro: 75 0 0 13 25 0 13 0 0 0 0 0 63 0 63 % P
% Gln: 0 0 13 0 0 25 0 0 13 0 0 0 0 13 0 % Q
% Arg: 0 0 0 0 0 13 0 0 13 0 13 0 13 50 0 % R
% Ser: 0 0 0 13 0 13 0 75 13 0 13 63 0 13 25 % S
% Thr: 0 0 13 13 25 13 0 0 0 13 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 13 0 0 % W
% Tyr: 0 13 0 0 0 13 0 0 0 50 13 0 13 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _