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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SCARB2
All Species:
31.52
Human Site:
T421
Identified Species:
57.78
UniProt:
Q14108
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14108
NP_005497.1
478
54290
T421
S
V
H
I
D
K
E
T
A
S
R
L
K
S
M
Chimpanzee
Pan troglodytes
XP_517214
478
54291
T421
S
V
H
I
D
K
E
T
A
S
R
L
K
S
M
Rhesus Macaque
Macaca mulatta
XP_001096458
478
54263
T421
S
V
L
I
D
K
E
T
A
S
R
L
K
S
V
Dog
Lupus familis
XP_535612
447
50655
A391
V
L
I
D
K
D
T
A
S
R
L
K
S
V
I
Cat
Felis silvestris
Mouse
Mus musculus
O35114
478
54026
T421
S
V
L
I
D
K
E
T
A
N
Q
L
K
S
V
Rat
Rattus norvegicus
P27615
478
54072
T421
S
V
L
I
D
K
E
T
A
S
Q
L
K
S
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518101
480
53897
S422
S
V
L
I
D
E
D
S
V
K
K
L
R
S
V
Chicken
Gallus gallus
XP_420593
481
53889
S424
S
V
L
I
D
E
A
S
A
N
K
L
K
H
V
Frog
Xenopus laevis
NP_001088246
483
54672
S425
S
V
L
I
D
D
K
S
A
E
K
L
R
S
I
Zebra Danio
Brachydanio rerio
NP_775366
531
60216
S429
T
A
T
I
D
D
E
S
A
A
Q
M
R
M
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q27367
457
52316
I401
Q
V
H
G
R
I
Q
I
N
M
M
I
E
P
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11124
563
62684
V501
G
A
Y
P
L
A
W
V
N
E
S
F
Y
M
D
Sea Urchin
Strong. purpuratus
XP_785055
366
41141
P310
F
A
N
Y
T
I
Y
P
P
N
I
G
F
C
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.7
79.9
N.A.
85.7
85.9
N.A.
65.2
59.2
51.9
41.6
N.A.
30.9
N.A.
28.6
31.5
Protein Similarity:
100
99.7
99.5
89.5
N.A.
95.8
95.1
N.A.
81
77.5
71.6
63.4
N.A.
49.1
N.A.
46.1
46.4
P-Site Identity:
100
100
86.6
0
N.A.
73.3
80
N.A.
40
46.6
46.6
26.6
N.A.
13.3
N.A.
0
0
P-Site Similarity:
100
100
93.3
20
N.A.
93.3
93.3
N.A.
80
80
80
73.3
N.A.
33.3
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
0
0
8
8
8
62
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
8
70
24
8
0
0
0
0
0
0
0
16
% D
% Glu:
0
0
0
0
0
16
47
0
0
16
0
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% F
% Gly:
8
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
24
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
8
70
0
16
0
8
0
0
8
8
0
0
16
% I
% Lys:
0
0
0
0
8
39
8
0
0
8
24
8
47
0
0
% K
% Leu:
0
8
47
0
8
0
0
0
0
0
8
62
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
8
8
0
16
16
% M
% Asn:
0
0
8
0
0
0
0
0
16
24
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
8
8
0
0
0
0
8
0
% P
% Gln:
8
0
0
0
0
0
8
0
0
0
24
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
8
24
0
24
0
0
% R
% Ser:
62
0
0
0
0
0
0
31
8
31
8
0
8
54
0
% S
% Thr:
8
0
8
0
8
0
8
39
0
0
0
0
0
0
8
% T
% Val:
8
70
0
0
0
0
0
8
8
0
0
0
0
8
39
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _