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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE1C
All Species:
17.88
Human Site:
S468
Identified Species:
49.17
UniProt:
Q14123
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14123
NP_005011.1
709
80760
S468
G
G
T
G
Q
R
R
S
S
L
N
S
I
S
S
Chimpanzee
Pan troglodytes
XP_515959
553
63273
N344
Q
Q
I
K
N
I
R
N
S
L
Q
Q
P
E
G
Rhesus Macaque
Macaca mulatta
XP_001083512
708
80789
S468
G
G
T
G
Q
R
R
S
S
L
N
S
I
S
S
Dog
Lupus familis
XP_852114
670
75871
S458
G
S
A
P
I
N
S
S
V
I
P
V
D
Y
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64338
706
80272
S468
G
G
T
G
Q
R
R
S
S
L
N
S
I
N
S
Rat
Rattus norvegicus
Q63421
768
86653
S528
G
G
T
G
Q
R
R
S
S
L
N
S
I
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516743
622
70017
A413
L
S
L
M
L
H
T
A
D
I
S
H
P
A
K
Chicken
Gallus gallus
XP_418850
599
68575
W390
A
W
D
L
H
H
R
W
T
M
S
L
L
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918973
762
86063
S522
G
L
A
G
F
R
R
S
S
L
N
N
I
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.7
97.1
90.4
N.A.
94.6
84.7
N.A.
69.3
70.8
N.A.
57.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
67.1
98.5
92.6
N.A.
97.4
88
N.A.
75.3
77.4
N.A.
69.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
20
100
13.3
N.A.
93.3
93.3
N.A.
0
6.6
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
100
20
N.A.
100
100
N.A.
26.6
33.3
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
23
0
0
0
0
12
0
0
0
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
0
0
0
0
0
12
0
0
0
12
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
23
12
% E
% Phe:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
67
45
0
56
0
0
0
0
0
0
0
0
0
0
12
% G
% His:
0
0
0
0
12
23
0
0
0
0
0
12
0
0
0
% H
% Ile:
0
0
12
0
12
12
0
0
0
23
0
0
56
0
0
% I
% Lys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
23
% K
% Leu:
12
12
12
12
12
0
0
0
0
67
0
12
12
0
0
% L
% Met:
0
0
0
12
0
0
0
0
0
12
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
12
0
12
0
0
56
12
0
23
0
% N
% Pro:
0
0
0
12
0
0
0
0
0
0
12
0
23
12
0
% P
% Gln:
12
12
0
0
45
0
0
0
0
0
12
12
0
0
0
% Q
% Arg:
0
0
0
0
0
56
78
0
0
0
0
0
0
0
0
% R
% Ser:
0
23
0
0
0
0
12
67
67
0
23
45
0
23
56
% S
% Thr:
0
0
45
0
0
0
12
0
12
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
12
0
0
12
0
0
0
% V
% Trp:
0
12
0
0
0
0
0
12
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _