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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KEAP1
All Species:
19.39
Human Site:
Y263
Identified Species:
35.56
UniProt:
Q14145
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14145
NP_036421.2
624
69666
Y263
D
C
E
Q
R
R
F
Y
V
Q
A
L
L
R
A
Chimpanzee
Pan troglodytes
XP_512371
992
106974
Y631
D
C
E
Q
R
R
F
Y
V
Q
A
L
L
R
A
Rhesus Macaque
Macaca mulatta
XP_001105867
525
58783
V167
V
M
Y
Q
I
D
S
V
V
R
A
C
S
D
F
Dog
Lupus familis
XP_533917
624
69690
Y263
D
C
E
Q
R
R
F
Y
V
Q
A
L
L
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2X8
624
69534
Y263
D
C
P
Q
R
R
F
Y
V
Q
A
L
L
R
A
Rat
Rattus norvegicus
P57790
624
69380
Y263
D
C
P
Q
R
R
F
Y
V
Q
A
L
L
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515196
722
79884
S316
N
F
Q
E
V
M
E
S
E
E
F
M
L
L
P
Chicken
Gallus gallus
Q5ZI33
586
66177
D228
N
R
Q
P
Y
M
V
D
I
L
A
K
V
R
F
Frog
Xenopus laevis
Q6NRH0
564
63190
E206
W
V
K
H
N
R
H
E
R
E
K
S
L
P
Q
Zebra Danio
Brachydanio rerio
Q5U374
564
62914
E206
W
V
K
H
N
R
K
E
R
E
P
Y
L
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_732202
776
87372
K271
D
E
D
N
R
H
C
K
M
E
H
I
L
G
A
Honey Bee
Apis mellifera
XP_395147
616
69734
K252
N
E
E
A
R
G
P
K
M
E
H
I
L
H
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788744
1147
128850
C783
K
E
D
E
R
R
P
C
L
E
K
L
F
N
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.9
73.7
97.5
N.A.
94
93.7
N.A.
34.6
29.1
35.2
34.7
N.A.
37.5
47.9
N.A.
30.7
Protein Similarity:
100
62.9
76.9
98.5
N.A.
97.2
96.9
N.A.
50.2
47.5
50.9
51.1
N.A.
50.9
64
N.A.
40
P-Site Identity:
100
100
20
100
N.A.
93.3
93.3
N.A.
6.6
13.3
13.3
13.3
N.A.
26.6
26.6
N.A.
20
P-Site Similarity:
100
100
26.6
100
N.A.
93.3
93.3
N.A.
40
40
26.6
26.6
N.A.
53.3
53.3
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
0
54
0
0
0
54
% A
% Cys:
0
39
0
0
0
0
8
8
0
0
0
8
0
0
8
% C
% Asp:
47
0
16
0
0
8
0
8
0
0
0
0
0
8
8
% D
% Glu:
0
24
31
16
0
0
8
16
8
47
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
39
0
0
0
8
0
8
0
16
% F
% Gly:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
16
0
8
8
0
0
0
16
0
0
8
0
% H
% Ile:
0
0
0
0
8
0
0
0
8
0
0
16
0
0
0
% I
% Lys:
8
0
16
0
0
0
8
16
0
0
16
8
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
8
8
0
47
77
8
0
% L
% Met:
0
8
0
0
0
16
0
0
16
0
0
8
0
0
0
% M
% Asn:
24
0
0
8
16
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
16
8
0
0
16
0
0
0
8
0
0
16
8
% P
% Gln:
0
0
16
47
0
0
0
0
0
39
0
0
0
0
8
% Q
% Arg:
0
8
0
0
62
62
0
0
16
8
0
0
0
47
0
% R
% Ser:
0
0
0
0
0
0
8
8
0
0
0
8
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
16
0
0
8
0
8
8
47
0
0
0
8
0
0
% V
% Trp:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
0
39
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _