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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KEAP1
All Species:
30.61
Human Site:
Y443
Identified Species:
56.11
UniProt:
Q14145
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14145
NP_036421.2
624
69666
Y443
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
Chimpanzee
Pan troglodytes
XP_512371
992
106974
Y811
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
Rhesus Macaque
Macaca mulatta
XP_001105867
525
58783
Y345
S
L
S
Y
L
E
A
Y
N
P
S
D
G
T
W
Dog
Lupus familis
XP_533917
624
69690
Y443
H
H
N
S
V
E
R
Y
E
P
E
R
D
E
W
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2X8
624
69534
Y443
H
H
S
S
V
E
R
Y
E
P
E
R
D
E
W
Rat
Rattus norvegicus
P57790
624
69380
Y443
H
H
S
S
V
E
R
Y
E
P
D
R
D
E
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515196
722
79884
D499
L
N
S
V
E
R
Y
D
P
K
T
N
Q
W
S
Chicken
Gallus gallus
Q5ZI33
586
66177
R406
L
F
E
C
Y
D
T
R
T
E
S
W
H
T
K
Frog
Xenopus laevis
Q6NRH0
564
63190
D384
I
Y
V
S
G
G
F
D
G
S
R
R
H
T
S
Zebra Danio
Brachydanio rerio
Q5U374
564
62914
D384
I
Y
V
A
G
G
F
D
G
S
R
R
H
T
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_732202
776
87372
Y450
Y
H
N
T
V
E
Y
Y
D
P
D
L
D
R
W
Honey Bee
Apis mellifera
XP_395147
616
69734
Y431
Y
H
N
S
V
E
C
Y
D
P
E
H
D
S
W
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788744
1147
128850
Y964
Q
H
N
S
A
E
R
Y
N
P
D
D
E
K
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.9
73.7
97.5
N.A.
94
93.7
N.A.
34.6
29.1
35.2
34.7
N.A.
37.5
47.9
N.A.
30.7
Protein Similarity:
100
62.9
76.9
98.5
N.A.
97.2
96.9
N.A.
50.2
47.5
50.9
51.1
N.A.
50.9
64
N.A.
40
P-Site Identity:
100
100
26.6
100
N.A.
93.3
86.6
N.A.
0
0
13.3
6.6
N.A.
53.3
66.6
N.A.
53.3
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
13.3
6.6
20
20
N.A.
80
80
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
0
24
16
0
24
16
54
0
0
% D
% Glu:
0
0
8
0
8
70
0
0
39
8
39
0
8
39
0
% E
% Phe:
0
8
0
0
0
0
16
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
16
16
0
0
16
0
0
0
8
0
0
% G
% His:
39
62
0
0
0
0
0
0
0
0
0
8
24
0
0
% H
% Ile:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
8
% K
% Leu:
16
8
0
0
8
0
0
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
47
0
0
0
0
0
16
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
70
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
0
8
47
8
0
0
16
54
0
8
0
% R
% Ser:
8
0
31
62
0
0
0
0
0
16
16
0
0
8
24
% S
% Thr:
0
0
0
8
0
0
8
0
8
0
8
0
0
31
0
% T
% Val:
0
0
16
8
54
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
8
70
% W
% Tyr:
16
16
0
8
8
0
16
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _