Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3A All Species: 43.33
Human Site: S1195 Identified Species: 56.08
UniProt: Q14152 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14152 NP_003741.1 1382 166569 S1195 S W G P P R E S R P S E E R E
Chimpanzee Pan troglodytes XP_001153575 1382 166541 S1195 S W G P P R E S R P S E E R E
Rhesus Macaque Macaca mulatta XP_001102472 1228 147070 S1041 S W G P P R E S R P S E E R E
Dog Lupus familis XP_852131 1350 163016 S1156 S W G P P R E S R P S E E R E
Cat Felis silvestris
Mouse Mus musculus P23116 1344 161918 S1156 S W G P P R E S R P S E E R E
Rat Rattus norvegicus Q1JU68 1354 163177 S1166 S W G P P R E S R P P E E R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514639 1362 163866 S1185 S W G P P R E S R P S E D R D
Chicken Gallus gallus XP_421787 1505 177889 S1330 S W G P P R D S R P P G D R E
Frog Xenopus laevis A2VD00 1424 168482 S1293 S W G P S H D S K P P E E R D
Zebra Danio Brachydanio rerio Q6PCR7 1267 151273 S1115 S W G P P R D S G H D D D G G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VN25 1140 133861 D1024 G P R R D R D D G P R R D R D
Honey Bee Apis mellifera XP_397439 1143 134949 S1030 G G G S G G G S H R R E E T M
Nematode Worm Caenorhab. elegans P34339 1076 124390 P957 D V R R N D P P R P A S K A D
Sea Urchin Strong. purpuratus XP_798957 1284 149812 S1093 R D L G P R D S G R R E E R Y
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XHR2 962 111545 S856 R E K L L K G S E A V R A P D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LD55 987 114281 T880 T V T P V G T T A P A A A A A
Baker's Yeast Sacchar. cerevisiae P38249 964 110326 Q857 L A E A T R K Q R E I E E A A
Red Bread Mold Neurospora crassa Q7RWT1 1007 114509 A903 T A A P A P A A A E P V A E R
Conservation
Percent
Protein Identity: 100 99.9 86.5 94.2 N.A. 93.1 93.1 N.A. 88.2 75.6 72.1 75 N.A. 41.5 42.1 31.4 45.4
Protein Similarity: 100 99.9 87.4 95.9 N.A. 95.5 95.5 N.A. 93.1 81.7 81.4 82.1 N.A. 58 58.5 48.3 62.1
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 86.6 73.3 60 46.6 N.A. 20 26.6 13.3 40
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 100 86.6 80 66.6 N.A. 40 26.6 33.3 46.6
Percent
Protein Identity: N.A. 27.2 N.A. 27.1 23.3 28.2
Protein Similarity: N.A. 43.8 N.A. 44.6 41 43.6
P-Site Identity: N.A. 6.6 N.A. 13.3 26.6 6.6
P-Site Similarity: N.A. 20 N.A. 33.3 33.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 6 6 6 0 6 6 12 6 12 6 17 17 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 6 6 0 0 6 6 28 6 0 0 6 6 23 0 28 % D
% Glu: 0 6 6 0 0 0 39 0 6 12 0 62 56 6 39 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 6 62 6 6 12 12 0 17 0 0 6 0 6 6 % G
% His: 0 0 0 0 0 6 0 0 6 6 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % I
% Lys: 0 0 6 0 0 6 6 0 6 0 0 0 6 0 0 % K
% Leu: 6 0 6 6 6 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % M
% Asn: 0 0 0 0 6 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 6 0 67 56 6 6 6 0 67 23 0 0 6 0 % P
% Gln: 0 0 0 0 0 0 0 6 0 0 0 0 0 0 0 % Q
% Arg: 12 0 12 12 0 67 0 0 56 12 17 12 0 62 6 % R
% Ser: 56 0 0 6 6 0 0 73 0 0 34 6 0 0 0 % S
% Thr: 12 0 6 0 6 0 6 6 0 0 0 0 0 6 0 % T
% Val: 0 12 0 0 6 0 0 0 0 0 6 6 0 0 0 % V
% Trp: 0 56 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _