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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
53.33
Human Site:
S225
Identified Species:
69.02
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
D218
M
R
K
N
L
T
Q
D
E
M
Q
R
M
S
T
Dog
Lupus familis
XP_852131
1350
163016
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Rat
Rattus norvegicus
Q1JU68
1354
163177
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
S247
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Chicken
Gallus gallus
XP_421787
1505
177889
S356
I
N
L
N
N
P
D
S
Q
S
M
H
L
E
T
Frog
Xenopus laevis
A2VD00
1424
168482
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
S225
I
N
L
N
N
P
E
S
Q
S
M
H
L
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
T229
V
S
I
N
K
V
E
T
Q
Q
L
C
L
D
T
Honey Bee
Apis mellifera
XP_397439
1143
134949
T227
V
S
M
N
R
A
E
T
Q
Q
L
N
L
E
T
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
S230
V
K
L
T
S
P
E
S
L
G
L
M
Q
D
T
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
S227
I
N
L
N
N
A
E
S
Q
Q
L
H
L
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
K211
N
H
L
A
N
L
N
K
Y
R
D
Q
R
D
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
S226
P
D
L
S
A
P
E
S
L
Q
L
Y
L
D
T
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
D211
E
M
L
R
Q
H
L
D
A
A
N
Y
Q
Q
S
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
A224
L
S
L
S
K
R
P
A
K
N
V
M
M
A
N
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
13.3
100
N.A.
100
100
N.A.
100
93.3
100
100
N.A.
33.3
40
33.3
73.3
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
80
60
86.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
40
6.6
6.6
P-Site Similarity:
N.A.
26.6
N.A.
73.3
33.3
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
6
6
12
0
6
6
6
0
0
0
6
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% C
% Asp:
0
6
0
0
0
0
6
12
0
0
6
0
0
28
0
% D
% Glu:
6
0
0
0
0
0
73
0
6
0
0
0
0
56
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
6
0
0
0
0
0
% G
% His:
0
6
0
0
0
6
0
0
0
0
0
56
0
0
0
% H
% Ile:
56
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
6
6
0
12
0
0
6
6
0
0
0
0
0
0
% K
% Leu:
6
0
84
0
6
6
6
0
12
0
28
0
73
0
0
% L
% Met:
6
6
6
0
0
0
0
0
0
6
50
12
12
0
0
% M
% Asn:
6
56
0
73
62
0
6
0
0
6
6
6
0
0
6
% N
% Pro:
6
0
0
0
0
62
6
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
6
0
6
0
67
23
6
6
12
6
0
% Q
% Arg:
0
6
0
6
6
6
0
0
0
6
0
6
6
0
6
% R
% Ser:
0
17
0
12
6
0
0
67
0
50
0
0
0
6
6
% S
% Thr:
0
0
0
6
0
6
0
12
0
0
0
0
0
0
84
% T
% Val:
17
0
0
0
0
6
0
0
0
0
6
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
6
0
0
12
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _