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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3A All Species: 51.52
Human Site: S449 Identified Species: 66.67
UniProt: Q14152 Number Species: 17
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14152 NP_003741.1 1382 166569 S449 Q V S Q I Y Q S I E F S R L T
Chimpanzee Pan troglodytes XP_001153575 1382 166541 S449 Q V S Q I Y Q S I E F S R L T
Rhesus Macaque Macaca mulatta XP_001102472 1228 147070 K437 A M S S V L A K A L E V I K P
Dog Lupus familis XP_852131 1350 163016 S449 Q V A Q I Y Q S I E F S R L T
Cat Felis silvestris
Mouse Mus musculus P23116 1344 161918 S449 Q V A Q I Y Q S I E F S R L T
Rat Rattus norvegicus Q1JU68 1354 163177 S449 Q V A Q I Y Q S I E F S R L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514639 1362 163866 S471 Q V A Q I Y Q S I E F S R L T
Chicken Gallus gallus XP_421787 1505 177889 S580 Q V A Q I Y Q S I E F S R L A
Frog Xenopus laevis A2VD00 1424 168482 T449 Q V A Q I Y Q T I E F S R L S
Zebra Danio Brachydanio rerio Q6PCR7 1267 151273 S449 Q V A Q I Y Q S I E F S R L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VN25 1140 133861 S452 Q I S Q V Y E S I K F Q R L L
Honey Bee Apis mellifera XP_397439 1143 134949 T449 Q I S Q V Y Q T I K F A R L L
Nematode Worm Caenorhab. elegans P34339 1076 124390 A454 Q V S V I Y E A I S W E R I R
Sea Urchin Strong. purpuratus XP_798957 1284 149812 T449 Q V S E V Y E T I E M S R I Y
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XHR2 962 111545 S420 Q P L L L K I S K I G G K L S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LD55 987 114281 L439 P S L P E V Q L S Q Y V P S L
Baker's Yeast Sacchar. cerevisiae P38249 964 110326 S418 L S S K T Y F S Q Y I A P L R
Red Bread Mold Neurospora crassa Q7RWT1 1007 114509 I442 R G T I E K F I M N G N K K G
Conservation
Percent
Protein Identity: 100 99.9 86.5 94.2 N.A. 93.1 93.1 N.A. 88.2 75.6 72.1 75 N.A. 41.5 42.1 31.4 45.4
Protein Similarity: 100 99.9 87.4 95.9 N.A. 95.5 95.5 N.A. 93.1 81.7 81.4 82.1 N.A. 58 58.5 48.3 62.1
P-Site Identity: 100 100 6.6 93.3 N.A. 93.3 93.3 N.A. 93.3 86.6 80 86.6 N.A. 60 60 46.6 53.3
P-Site Similarity: 100 100 20 100 N.A. 100 100 N.A. 100 93.3 100 93.3 N.A. 86.6 93.3 73.3 86.6
Percent
Protein Identity: N.A. 27.2 N.A. 27.1 23.3 28.2
Protein Similarity: N.A. 43.8 N.A. 44.6 41 43.6
P-Site Identity: N.A. 20 N.A. 6.6 26.6 0
P-Site Similarity: N.A. 40 N.A. 20 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 39 0 0 0 6 6 6 0 0 12 0 0 12 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 6 12 0 17 0 0 56 6 6 0 0 0 % E
% Phe: 0 0 0 0 0 0 12 0 0 0 62 0 0 0 0 % F
% Gly: 0 6 0 0 0 0 0 0 0 0 12 6 0 0 6 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 12 0 6 56 0 6 6 73 6 6 0 6 12 0 % I
% Lys: 0 0 0 6 0 12 0 6 6 12 0 0 12 12 0 % K
% Leu: 6 0 12 6 6 6 0 6 0 6 0 0 0 73 17 % L
% Met: 0 6 0 0 0 0 0 0 6 0 6 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 6 0 6 0 0 0 % N
% Pro: 6 6 0 6 0 0 0 0 0 0 0 0 12 0 6 % P
% Gln: 78 0 0 62 0 0 62 0 6 6 0 6 0 0 0 % Q
% Arg: 6 0 0 0 0 0 0 0 0 0 0 0 73 0 12 % R
% Ser: 0 12 45 6 0 0 0 62 6 6 0 56 0 6 12 % S
% Thr: 0 0 6 0 6 0 0 17 0 0 0 0 0 0 34 % T
% Val: 0 62 0 6 23 6 0 0 0 0 0 12 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % W
% Tyr: 0 0 0 0 0 78 0 0 0 6 6 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _