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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
40
Human Site:
S488
Identified Species:
51.76
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
A461
Q
H
Q
L
A
V
T
A
Y
L
K
N
S
R
K
Dog
Lupus familis
XP_852131
1350
163016
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Rat
Rattus norvegicus
Q1JU68
1354
163177
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
S510
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Chicken
Gallus gallus
XP_421787
1505
177889
T619
Q
V
R
L
D
H
T
T
R
T
L
S
F
G
S
Frog
Xenopus laevis
A2VD00
1424
168482
S488
Q
V
R
I
D
H
T
S
R
T
L
S
F
G
S
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
S488
Q
V
R
I
D
H
S
S
R
T
L
S
F
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
K491
Q
I
R
I
D
H
Q
K
N
S
I
Y
F
G
T
Honey Bee
Apis mellifera
XP_397439
1143
134949
K488
Q
I
R
I
S
H
G
K
K
C
V
H
F
G
V
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
G499
R
A
D
C
V
R
F
G
S
S
D
A
T
L
A
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
Q489
V
R
V
D
H
A
K
Q
C
L
V
F
G
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
E445
S
Q
Y
I
S
A
L
E
K
L
T
T
L
R
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
T464
Q
V
S
K
I
Y
Q
T
I
R
I
E
S
L
S
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
T442
A
A
S
Q
K
F
T
T
V
S
Q
S
E
L
Y
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
S471
F
D
A
D
V
F
S
S
A
K
A
V
H
A
G
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
13.3
100
N.A.
100
100
N.A.
100
86.6
100
93.3
N.A.
46.6
40
0
0
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
60
26.6
6.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
6.6
N.A.
20
13.3
6.6
P-Site Similarity:
N.A.
20
N.A.
40
26.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
12
6
0
6
12
0
6
6
0
6
6
0
6
6
% A
% Cys:
0
0
0
6
0
0
0
0
6
6
0
0
0
0
0
% C
% Asp:
0
6
6
12
56
0
0
0
0
0
6
0
0
0
6
% D
% Glu:
0
0
0
0
0
0
0
6
0
0
0
6
6
0
0
% E
% Phe:
6
0
0
0
0
12
6
0
0
0
0
6
62
0
0
% F
% Gly:
0
0
0
0
0
0
6
6
0
0
0
0
6
62
6
% G
% His:
0
6
0
0
6
62
0
0
0
0
0
6
6
0
0
% H
% Ile:
0
12
0
62
6
0
0
0
6
0
12
0
0
0
0
% I
% Lys:
0
0
0
6
6
0
6
12
12
6
6
0
0
0
6
% K
% Leu:
0
0
0
12
0
0
6
0
0
17
50
0
6
17
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
6
0
0
6
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
73
6
6
6
0
0
12
6
0
0
6
0
0
0
0
% Q
% Arg:
6
6
62
0
0
6
0
0
50
6
0
0
0
12
0
% R
% Ser:
6
0
12
0
12
0
12
50
6
17
0
56
12
6
56
% S
% Thr:
0
0
0
0
0
0
56
17
0
50
6
6
6
0
6
% T
% Val:
6
56
6
0
12
6
0
0
6
0
12
6
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
6
0
0
6
0
0
6
0
0
6
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _