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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
31.82
Human Site:
S584
Identified Species:
41.18
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
K550
E
R
L
E
Q
I
K
K
T
E
L
G
A
K
A
Dog
Lupus familis
XP_852131
1350
163016
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Rat
Rattus norvegicus
Q1JU68
1354
163177
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
S606
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Chicken
Gallus gallus
XP_421787
1505
177889
S715
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Frog
Xenopus laevis
A2VD00
1424
168482
N584
E
R
K
E
R
L
E
N
L
N
I
Q
R
E
K
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
S584
E
R
K
E
R
L
E
S
L
N
I
Q
R
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
K587
D
R
K
E
Y
I
E
K
Q
N
N
A
R
E
E
Honey Bee
Apis mellifera
XP_397439
1143
134949
H584
E
R
K
E
Y
I
E
H
I
N
T
V
R
E
E
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
R595
N
Y
K
E
N
W
E
R
V
K
A
E
K
T
A
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
N585
D
R
K
E
R
L
E
N
L
T
V
Q
R
E
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
K529
V
L
A
D
S
L
N
K
A
R
I
H
I
C
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
G548
S
K
A
S
K
L
A
G
V
I
P
N
L
A
D
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
A527
E
K
E
E
T
D
E
A
L
G
P
Q
E
T
E
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
E566
T
R
K
D
K
A
S
E
A
Q
A
Q
K
E
K
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
20
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
46.6
53.3
20
66.6
P-Site Similarity:
100
100
53.3
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
66.6
73.3
40
93.3
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
6.6
33.3
33.3
P-Site Similarity:
N.A.
20
N.A.
26.6
60
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
0
6
6
6
12
0
12
6
6
6
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% C
% Asp:
12
0
0
12
0
6
0
0
0
0
0
0
0
0
6
% D
% Glu:
67
0
6
84
0
0
78
6
0
6
0
6
6
73
17
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
6
0
6
0
6
0
0
0
% G
% His:
0
0
0
0
0
0
0
6
0
0
0
6
0
0
0
% H
% Ile:
0
0
0
0
0
17
0
0
6
6
56
0
6
0
0
% I
% Lys:
0
12
78
0
12
0
6
17
0
6
0
0
12
6
56
% K
% Leu:
0
6
6
0
0
67
0
0
62
0
6
0
6
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
0
0
0
6
0
6
12
0
62
6
6
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
6
% P
% Gln:
0
0
0
0
6
0
0
0
6
6
0
67
0
0
0
% Q
% Arg:
0
78
0
0
56
0
0
6
0
6
0
0
67
0
6
% R
% Ser:
6
0
0
6
6
0
6
45
0
0
0
0
0
0
0
% S
% Thr:
6
0
0
0
6
0
0
0
6
6
6
0
0
12
0
% T
% Val:
6
0
0
0
0
0
0
0
12
0
6
6
0
0
0
% V
% Trp:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
0
0
12
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _