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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
37.58
Human Site:
S770
Identified Species:
48.63
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
A668
E
R
E
E
R
E
R
A
E
R
A
K
R
E
E
Dog
Lupus familis
XP_852131
1350
163016
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Rat
Rattus norvegicus
Q1JU68
1354
163177
S770
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
S792
R
L
K
A
A
R
Q
S
V
Y
E
E
K
L
K
Chicken
Gallus gallus
XP_421787
1505
177889
T901
R
L
K
A
L
R
R
T
V
Y
E
D
K
L
K
Frog
Xenopus laevis
A2VD00
1424
168482
S770
N
L
K
A
S
R
Q
S
V
Y
D
A
K
L
K
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
F770
K
I
K
A
A
R
S
F
I
Y
E
E
K
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
S773
A
L
K
K
E
R
A
S
L
Y
V
E
K
L
K
Honey Bee
Apis mellifera
XP_397439
1143
134949
S770
K
I
L
A
E
R
K
S
I
Y
L
E
K
L
K
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
A712
N
F
D
H
H
V
R
A
L
H
L
E
E
L
N
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
N773
M
L
R
Q
T
R
L
N
L
Y
Q
E
K
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
L634
K
A
E
A
K
K
M
L
E
D
L
N
K
A
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
L652
K
G
K
K
K
P
L
L
D
G
E
K
V
T
K
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
Q632
Q
D
A
E
V
R
Q
Q
R
I
L
E
E
K
A
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
K678
H
L
E
R
A
F
R
K
E
E
A
K
K
L
P
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
100
73.3
73.3
66.6
N.A.
60
53.3
13.3
40
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
93.3
86.6
86.6
N.A.
66.6
80
46.6
66.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
20
20
26.6
P-Site Similarity:
N.A.
33.3
N.A.
33.3
33.3
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
6
62
45
0
6
12
0
0
12
6
0
6
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
6
0
0
0
0
0
6
6
6
6
0
0
0
% D
% Glu:
6
0
17
12
12
6
0
0
17
6
50
67
12
6
6
% E
% Phe:
0
6
0
0
0
6
0
6
0
0
0
0
0
0
0
% F
% Gly:
0
6
0
0
0
0
0
0
0
6
0
0
0
0
6
% G
% His:
6
0
0
6
6
0
0
0
0
6
0
0
0
0
0
% H
% Ile:
0
12
0
0
0
0
0
0
12
6
0
0
0
0
0
% I
% Lys:
23
0
62
12
12
6
6
6
0
0
0
17
78
6
67
% K
% Leu:
0
62
6
0
6
0
12
12
17
0
23
0
0
78
0
% L
% Met:
6
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
0
0
0
0
0
6
0
0
0
6
0
0
6
% N
% Pro:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
6
% P
% Gln:
6
0
0
6
0
0
45
6
0
0
6
0
0
0
0
% Q
% Arg:
39
6
6
6
6
73
23
0
6
6
0
0
6
0
0
% R
% Ser:
0
0
0
0
6
0
6
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
6
0
0
6
0
0
0
0
0
6
0
% T
% Val:
0
0
0
0
6
6
0
0
45
0
6
0
6
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
67
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _