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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
30.3
Human Site:
S978
Identified Species:
39.22
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
S978
G
P
E
E
D
R
F
S
R
R
G
A
D
D
D
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
S978
G
P
E
E
D
R
F
S
R
R
G
A
D
D
D
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
S814
G
P
E
E
D
R
F
S
R
R
G
A
D
D
D
Dog
Lupus familis
XP_852131
1350
163016
S978
G
L
D
E
D
R
F
S
R
R
G
A
D
D
D
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
S978
G
P
D
E
D
R
F
S
R
R
G
T
D
D
D
Rat
Rattus norvegicus
Q1JU68
1354
163177
S978
G
P
D
E
D
R
F
S
R
R
G
T
D
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
P1000
G
V
D
E
D
R
F
P
R
R
S
A
D
E
D
Chicken
Gallus gallus
XP_421787
1505
177889
P1134
G
L
D
E
D
R
P
P
R
R
G
L
D
D
D
Frog
Xenopus laevis
A2VD00
1424
168482
P999
G
F
E
D
D
Q
G
P
R
R
G
L
D
E
D
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
T981
G
F
D
D
D
R
G
T
R
R
G
F
D
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
S904
G
G
D
R
P
S
A
S
N
G
G
S
S
E
W
Honey Bee
Apis mellifera
XP_397439
1143
134949
S910
Q
E
K
P
V
E
M
S
W
R
R
P
V
D
A
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
G842
A
R
L
Q
V
I
E
G
Q
R
R
Q
H
N
D
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
Q936
P
D
S
E
E
R
V
Q
Q
Q
E
A
A
P
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
E754
L
Q
E
R
I
I
Q
E
R
A
A
E
F
G
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
S777
T
E
R
E
E
R
I
S
K
I
I
R
E
K
K
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
E754
E
T
D
T
A
N
Y
E
A
M
K
K
K
I
V
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
E800
A
A
R
E
K
E
E
E
R
K
R
L
E
A
R
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
66.6
66.6
53.3
60
N.A.
20
20
13.3
20
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
80
73.3
73.3
80
N.A.
40
26.6
33.3
40
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
20
0
13.3
P-Site Similarity:
N.A.
13.3
N.A.
40
13.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
6
0
0
6
0
6
0
6
6
6
34
6
6
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
45
12
56
0
0
0
0
0
0
0
56
50
62
% D
% Glu:
6
12
28
62
12
12
12
17
0
0
6
6
12
17
0
% E
% Phe:
0
12
0
0
0
0
39
0
0
0
0
6
6
0
0
% F
% Gly:
62
6
0
0
0
0
12
6
0
6
56
0
0
6
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% H
% Ile:
0
0
0
0
6
12
6
0
0
6
6
0
0
6
0
% I
% Lys:
0
0
6
0
6
0
0
0
6
6
6
6
6
6
6
% K
% Leu:
6
12
6
0
0
0
0
0
0
0
0
17
0
0
0
% L
% Met:
0
0
0
0
0
0
6
0
0
6
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
6
0
0
6
0
0
0
0
6
0
% N
% Pro:
6
28
0
6
6
0
6
17
0
0
0
6
0
6
6
% P
% Gln:
6
6
0
6
0
6
6
6
12
6
0
6
0
0
0
% Q
% Arg:
0
6
12
12
0
62
0
0
67
67
17
6
0
0
12
% R
% Ser:
0
0
6
0
0
6
0
50
0
0
6
6
6
0
0
% S
% Thr:
6
6
0
6
0
0
0
6
0
0
0
12
0
0
0
% T
% Val:
0
6
0
0
12
0
6
0
0
0
0
0
6
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
6
% W
% Tyr:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _