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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
42.12
Human Site:
T524
Identified Species:
54.51
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0.24
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
E497
L
N
I
Q
R
E
K
E
E
L
E
Q
R
E
A
Dog
Lupus familis
XP_852131
1350
163016
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Rat
Rattus norvegicus
Q1JU68
1354
163177
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
T546
E
Q
I
R
N
Q
L
T
A
M
S
S
V
L
A
Chicken
Gallus gallus
XP_421787
1505
177889
T655
E
Q
I
R
N
Q
L
T
A
M
S
S
A
L
A
Frog
Xenopus laevis
A2VD00
1424
168482
T524
E
H
I
R
N
Q
L
T
A
M
S
T
V
L
S
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
T524
E
Q
I
R
N
Q
L
T
A
M
S
S
S
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
V527
E
Q
I
R
S
Q
L
V
N
M
S
T
V
L
T
Honey Bee
Apis mellifera
XP_397439
1143
134949
V524
E
Q
I
R
C
Q
L
V
N
M
A
T
V
L
H
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
E535
E
G
V
R
N
H
L
E
A
M
Y
T
R
L
R
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
T525
Q
Q
I
R
H
Q
L
T
Q
M
S
S
A
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
E481
F
F
D
F
S
V
V
E
K
I
S
V
D
A
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
D500
N
F
V
A
M
K
V
D
H
M
K
G
V
V
I
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
V478
Q
A
A
V
E
D
Y
V
S
I
T
I
D
H
E
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
T507
Q
I
V
R
S
Q
L
T
R
L
A
E
A
L
Y
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
13.3
100
N.A.
100
100
N.A.
100
93.3
80
93.3
N.A.
66.6
60
46.6
66.6
P-Site Similarity:
100
100
33.3
100
N.A.
100
100
N.A.
100
93.3
93.3
93.3
N.A.
80
73.3
60
80
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
13.3
0
33.3
P-Site Similarity:
N.A.
33.3
N.A.
40
26.6
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
6
0
0
0
0
56
0
12
0
17
6
56
% A
% Cys:
0
0
0
0
6
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
6
0
0
6
0
6
0
0
0
0
12
0
0
% D
% Glu:
67
0
0
0
6
6
0
17
6
0
6
6
0
6
6
% E
% Phe:
6
12
0
6
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
6
0
0
0
0
0
0
0
0
0
6
0
0
0
% G
% His:
0
6
0
0
6
6
0
0
6
0
0
0
0
6
6
% H
% Ile:
0
6
73
0
0
0
0
0
0
12
0
6
0
0
6
% I
% Lys:
0
0
0
0
0
6
6
0
6
0
6
0
0
0
0
% K
% Leu:
6
0
0
0
0
0
78
0
0
12
0
0
0
78
0
% L
% Met:
0
0
0
0
6
0
0
0
0
78
0
0
0
0
0
% M
% Asn:
6
6
0
0
56
0
0
0
12
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
17
62
0
6
0
73
0
0
6
0
0
6
0
0
0
% Q
% Arg:
0
0
0
78
6
0
0
0
6
0
0
0
12
0
6
% R
% Ser:
0
0
0
0
17
0
0
0
6
0
67
50
6
0
6
% S
% Thr:
0
0
0
0
0
0
0
62
0
0
6
23
0
0
6
% T
% Val:
0
0
17
6
0
6
12
17
0
0
0
6
56
6
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
6
0
0
0
6
0
0
0
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _