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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
42.42
Human Site:
T635
Identified Species:
54.9
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
I574
E
E
L
D
P
D
F
I
M
A
K
Q
V
E
Q
Dog
Lupus familis
XP_852131
1350
163016
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Rat
Rattus norvegicus
Q1JU68
1354
163177
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
T657
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Chicken
Gallus gallus
XP_421787
1505
177889
T766
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Frog
Xenopus laevis
A2VD00
1424
168482
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
T635
H
E
Q
I
K
K
K
T
V
R
E
R
L
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
S638
I
Q
A
I
R
E
K
S
L
K
E
K
V
Q
Q
Honey Bee
Apis mellifera
XP_397439
1143
134949
H635
I
Q
Q
I
K
D
R
H
L
K
E
K
M
Q
Q
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
E619
E
E
A
A
R
A
E
E
M
K
R
L
D
E
Q
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
H636
M
E
E
M
K
R
K
H
A
K
E
R
I
N
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
L544
P
V
K
K
P
S
K
L
G
E
S
L
I
S
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
R563
T
V
E
K
E
H
K
R
L
L
A
R
K
S
I
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
S543
G
E
E
K
E
E
E
S
D
P
V
I
I
R
N
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
A589
Q
E
Q
A
L
Q
Q
A
E
A
A
R
L
A
E
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
20
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
26.6
33.3
20
33.3
P-Site Similarity:
100
100
46.6
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
80
46.6
66.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
6.6
N.A.
13.3
6.6
26.6
P-Site Similarity:
N.A.
20
N.A.
33.3
46.6
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
12
0
6
0
6
6
12
12
0
0
6
6
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
6
0
12
0
0
6
0
0
0
6
0
0
% D
% Glu:
12
78
17
0
12
12
12
6
6
6
67
0
0
62
6
% E
% Phe:
0
0
0
0
0
0
6
0
0
0
0
0
0
0
0
% F
% Gly:
6
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% G
% His:
50
0
0
0
0
6
0
12
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
62
0
0
0
6
0
0
0
6
17
0
6
% I
% Lys:
0
0
6
17
62
50
73
0
0
23
6
12
6
0
0
% K
% Leu:
0
0
6
0
6
0
0
6
17
6
0
12
56
0
6
% L
% Met:
6
0
0
6
0
0
0
0
12
0
0
0
6
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
6
% N
% Pro:
6
0
0
0
12
0
0
0
0
6
0
0
0
0
0
% P
% Gln:
6
12
62
0
0
6
6
0
0
0
0
6
0
12
73
% Q
% Arg:
0
0
0
0
12
6
6
6
0
50
6
67
0
6
0
% R
% Ser:
0
0
0
0
0
6
0
12
0
0
6
0
0
12
0
% S
% Thr:
6
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% T
% Val:
0
12
0
0
0
0
0
0
50
0
6
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _