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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3A All Species: 31.52
Human Site: T898 Identified Species: 40.78
UniProt: Q14152 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0.12
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14152 NP_003741.1 1382 166569 T898 G D R D S E G T W R K G P E A
Chimpanzee Pan troglodytes XP_001153575 1382 166541 T898 G D R D S E G T W R K G P E A
Rhesus Macaque Macaca mulatta XP_001102472 1228 147070 T734 G D R D S E G T W R K G P E A
Dog Lupus familis XP_852131 1350 163016 T898 G D R D S E G T W R K G P E V
Cat Felis silvestris
Mouse Mus musculus P23116 1344 161918 T898 G D R D S E G T W R K G P E A
Rat Rattus norvegicus Q1JU68 1354 163177 T898 G D R D S E G T W R K G P E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514639 1362 163866 T920 G D R D S E G T W R K S A E P
Chicken Gallus gallus XP_421787 1505 177889 S1030 D R G E S E S S W R R G G E T
Frog Xenopus laevis A2VD00 1424 168482 S898 R W G D R E E S G W R R G A D
Zebra Danio Brachydanio rerio Q6PCR7 1267 151273 G894 W A E R E E S G W R K R G E G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VN25 1140 133861 E846 R R L E R E A E D E K R R A Q
Honey Bee Apis mellifera XP_397439 1143 134949 E852 R L R R A E E E A R E A E R L
Nematode Worm Caenorhab. elegans P34339 1076 124390 K785 D N Q E T L E K K L S D W Q A
Sea Urchin Strong. purpuratus XP_798957 1284 149812 S872 R M K D T R P S E P E R T W R
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XHR2 962 111545 A700 E A P L I E Q A F Q K R L E E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LD55 987 114281 E719 V E E R E F Y E R E Q Q R E V
Baker's Yeast Sacchar. cerevisiae P38249 964 110326 Q699 L D L D T I K Q V I I A E V S
Red Bread Mold Neurospora crassa Q7RWT1 1007 114509 F746 H E R R R D E F E K R R R D A
Conservation
Percent
Protein Identity: 100 99.9 86.5 94.2 N.A. 93.1 93.1 N.A. 88.2 75.6 72.1 75 N.A. 41.5 42.1 31.4 45.4
Protein Similarity: 100 99.9 87.4 95.9 N.A. 95.5 95.5 N.A. 93.1 81.7 81.4 82.1 N.A. 58 58.5 48.3 62.1
P-Site Identity: 100 100 100 93.3 N.A. 100 100 N.A. 80 40 13.3 33.3 N.A. 13.3 20 6.6 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. 80 60 26.6 33.3 N.A. 20 33.3 40 33.3
Percent
Protein Identity: N.A. 27.2 N.A. 27.1 23.3 28.2
Protein Similarity: N.A. 43.8 N.A. 44.6 41 43.6
P-Site Identity: N.A. 20 N.A. 6.6 13.3 13.3
P-Site Similarity: N.A. 33.3 N.A. 20 26.6 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 0 6 0 6 6 6 0 0 12 6 12 39 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 45 0 56 0 6 0 0 6 0 0 6 0 6 6 % D
% Glu: 6 12 12 17 12 73 23 17 12 12 12 0 12 62 6 % E
% Phe: 0 0 0 0 0 6 0 6 6 0 0 0 0 0 0 % F
% Gly: 39 0 12 0 0 0 39 6 6 0 0 39 17 0 6 % G
% His: 6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 6 6 0 0 0 6 6 0 0 0 0 % I
% Lys: 0 0 6 0 0 0 6 6 6 6 56 0 0 0 0 % K
% Leu: 6 6 12 6 0 6 0 0 0 6 0 0 6 0 6 % L
% Met: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 6 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 6 0 0 0 6 0 0 6 0 0 34 0 6 % P
% Gln: 0 0 6 0 0 0 6 6 0 6 6 6 0 6 6 % Q
% Arg: 23 12 50 23 17 6 0 0 6 56 17 34 17 6 6 % R
% Ser: 0 0 0 0 45 0 12 17 0 0 6 6 0 0 6 % S
% Thr: 0 0 0 0 17 0 0 39 0 0 0 0 6 0 6 % T
% Val: 6 0 0 0 0 0 0 0 6 0 0 0 0 6 12 % V
% Trp: 6 6 0 0 0 0 0 0 50 6 0 0 6 6 0 % W
% Tyr: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _