KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
50.91
Human Site:
Y174
Identified Species:
65.88
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.12
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
F165
V
E
D
I
H
G
L
F
S
L
S
K
K
P
P
Dog
Lupus familis
XP_852131
1350
163016
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y174
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
Y196
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Chicken
Gallus gallus
XP_421787
1505
177889
Y305
N
S
R
V
E
R
L
Y
H
D
I
A
Q
Q
A
Frog
Xenopus laevis
A2VD00
1424
168482
Y174
N
S
K
V
E
R
L
Y
H
D
I
A
Q
Q
A
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y174
N
S
K
V
E
R
L
Y
H
D
I
A
Q
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
Y178
N
T
H
C
E
A
L
Y
H
D
I
A
R
M
A
Honey Bee
Apis mellifera
XP_397439
1143
134949
Y176
N
A
H
V
E
T
L
Y
H
D
I
A
R
M
A
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
Y175
N
A
Q
V
E
Q
L
Y
H
T
I
S
R
H
S
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
K174
R
N
N
N
R
L
E
K
L
Y
Q
D
V
A
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
V161
L
W
E
T
Y
R
T
V
L
E
I
L
R
N
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
Y175
N
S
K
L
E
A
L
Y
A
M
T
A
H
K
A
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
Y162
L
R
F
T
W
E
S
Y
R
A
V
L
D
L
L
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
K167
N
H
V
Q
T
A
A
K
Y
S
A
Q
M
H
A
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
100
100
93.3
93.3
N.A.
60
66.6
46.6
0
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
73.3
80
86.6
6.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
46.6
6.6
13.3
P-Site Similarity:
N.A.
26.6
N.A.
66.6
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
0
0
0
17
6
0
6
6
6
67
0
6
73
% A
% Cys:
0
0
0
6
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
6
0
0
0
0
0
0
62
0
6
6
0
0
% D
% Glu:
0
6
6
0
73
6
6
0
0
6
0
0
0
0
0
% E
% Phe:
0
0
6
0
0
0
0
6
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% G
% His:
0
6
12
0
6
0
0
0
67
0
0
0
6
12
0
% H
% Ile:
0
0
0
6
0
0
0
0
0
0
73
0
0
0
0
% I
% Lys:
0
0
17
0
0
0
0
12
0
0
0
6
6
6
0
% K
% Leu:
12
0
0
6
0
6
78
0
12
6
0
12
0
6
6
% L
% Met:
0
0
0
0
0
0
0
0
0
6
0
0
6
12
0
% M
% Asn:
78
6
6
6
0
0
0
0
0
0
0
0
0
6
6
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
6
% P
% Gln:
0
0
6
6
0
6
0
0
0
0
6
6
50
50
6
% Q
% Arg:
6
6
39
0
6
56
0
0
6
0
0
0
23
0
0
% R
% Ser:
0
56
0
0
0
0
6
0
6
6
6
6
0
0
6
% S
% Thr:
0
6
0
12
6
6
6
0
0
6
6
0
0
0
0
% T
% Val:
6
0
6
62
0
0
0
6
0
0
6
0
6
0
0
% V
% Trp:
0
6
0
0
6
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
6
0
0
78
6
6
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _