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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
52.12
Human Site:
Y188
Identified Species:
67.45
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0.12
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
N179
P
K
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
Dog
Lupus familis
XP_852131
1350
163016
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
Y210
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Chicken
Gallus gallus
XP_421787
1505
177889
Y319
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Frog
Xenopus laevis
A2VD00
1424
168482
Y188
A
F
K
F
C
L
L
Y
T
R
K
A
E
F
R
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y188
A
F
K
F
C
L
Q
Y
T
R
K
A
E
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
Y192
A
F
Q
F
C
L
K
Y
N
R
K
S
E
F
R
Honey Bee
Apis mellifera
XP_397439
1143
134949
Y190
A
F
Q
F
C
L
E
Y
N
R
K
T
E
F
R
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
Y189
S
F
T
F
C
L
R
Y
Q
R
R
T
E
F
R
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
Q188
Q
D
A
F
R
F
C
Q
K
Y
Q
R
K
T
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
Y175
N
S
K
L
E
A
L
Y
A
M
T
A
H
R
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
Y189
A
F
Q
F
C
K
Q
Y
K
R
T
T
E
F
R
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
E176
L
R
N
N
A
L
L
E
I
T
Y
S
G
V
V
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
D181
A
I
N
L
N
D
P
D
T
L
Q
R
H
L
E
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
73.3
73.3
60
6.6
P-Site Similarity:
100
100
6.6
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
93.3
86.6
80
20
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
20
N.A.
66.6
6.6
13.3
P-Site Similarity:
N.A.
20
N.A.
73.3
13.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
73
0
6
0
6
6
6
0
6
0
0
56
0
0
6
% A
% Cys:
0
0
0
0
73
0
6
0
0
0
0
0
0
0
0
% C
% Asp:
0
6
0
0
0
6
0
6
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
6
0
6
6
0
0
0
0
73
0
12
% E
% Phe:
0
73
0
78
0
6
0
0
0
0
0
0
0
73
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% H
% Ile:
0
6
0
0
0
0
0
0
6
0
0
0
0
0
0
% I
% Lys:
0
6
56
0
0
6
6
0
12
0
62
6
6
0
0
% K
% Leu:
6
0
0
12
6
73
17
0
0
6
0
0
0
6
0
% L
% Met:
0
0
0
0
0
6
0
0
0
6
0
0
0
0
0
% M
% Asn:
6
0
12
6
6
0
0
6
12
0
6
0
0
0
0
% N
% Pro:
6
0
6
0
0
0
6
0
0
0
0
0
0
0
0
% P
% Gln:
6
0
17
6
0
0
50
6
6
0
12
0
0
0
0
% Q
% Arg:
0
6
0
0
6
0
6
0
0
73
6
12
0
6
73
% R
% Ser:
6
6
0
0
0
0
0
0
0
0
0
12
0
6
0
% S
% Thr:
0
0
6
0
0
0
0
0
56
6
12
17
0
6
6
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
6
6
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
78
6
12
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _