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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
53.64
Human Site:
Y276
Identified Species:
69.41
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
Q267
L
A
T
L
L
G
L
Q
A
P
P
T
R
I
G
Dog
Lupus familis
XP_852131
1350
163016
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
Y298
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Chicken
Gallus gallus
XP_421787
1505
177889
Y407
P
Q
L
M
A
N
Y
Y
H
K
V
S
T
V
F
Frog
Xenopus laevis
A2VD00
1424
168482
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y276
P
Q
L
M
A
N
Y
Y
N
K
V
S
T
V
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
Y280
P
K
T
M
A
N
Y
Y
Q
K
L
A
M
V
F
Honey Bee
Apis mellifera
XP_397439
1143
134949
Y278
P
K
T
M
A
N
Y
Y
Q
K
L
A
M
V
F
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
Y285
P
A
S
Y
V
N
Y
Y
D
K
L
A
L
V
F
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
Y278
P
Q
M
M
A
N
Y
Y
H
K
L
G
L
V
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
H258
F
R
S
V
E
D
I
H
G
L
M
T
M
V
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
Y277
S
S
L
L
M
V
Y
Y
S
K
L
T
E
I
F
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
R258
E
L
W
H
E
A
Y
R
S
I
E
D
V
F
H
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
H271
A
A
L
I
A
S
G
H
S
K
K
A
D
N
P
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
100
93.3
100
100
N.A.
60
60
46.6
66.6
P-Site Similarity:
100
100
20
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
80
80
66.6
86.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
6.6
N.A.
33.3
6.6
20
P-Site Similarity:
N.A.
46.6
N.A.
66.6
13.3
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
17
0
0
73
6
0
0
6
0
0
23
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
6
0
0
6
0
0
6
6
0
0
% D
% Glu:
6
0
0
0
12
0
0
0
0
0
6
0
6
0
0
% E
% Phe:
6
0
0
0
0
0
0
0
0
0
0
0
0
6
78
% F
% Gly:
0
0
0
0
0
6
6
0
6
0
0
6
0
0
6
% G
% His:
0
0
0
6
0
0
0
12
12
0
0
0
0
0
6
% H
% Ile:
0
0
0
6
0
0
6
0
0
6
0
0
0
12
0
% I
% Lys:
0
12
0
0
0
0
0
0
0
84
6
0
0
0
6
% K
% Leu:
6
6
62
12
6
0
6
0
0
6
28
0
12
0
0
% L
% Met:
0
0
6
67
6
0
0
0
0
0
6
0
17
0
0
% M
% Asn:
0
0
0
0
0
73
0
0
45
0
0
0
0
6
0
% N
% Pro:
73
0
0
0
0
0
0
0
0
6
6
0
0
0
6
% P
% Gln:
0
56
0
0
0
0
0
6
12
0
0
0
0
0
0
% Q
% Arg:
0
6
0
0
0
0
0
6
0
0
0
0
6
0
0
% R
% Ser:
6
6
12
0
0
6
0
0
17
0
0
50
0
0
0
% S
% Thr:
0
0
17
0
0
0
0
0
0
0
0
17
50
0
0
% T
% Val:
0
0
0
6
6
6
0
0
0
0
50
0
6
78
0
% V
% Trp:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
6
0
0
84
78
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _