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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
31.82
Human Site:
Y382
Identified Species:
41.18
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y382
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y382
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
A375
D
A
F
Q
L
E
R
A
I
V
D
A
A
R
H
Dog
Lupus familis
XP_852131
1350
163016
Y382
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y382
V
R
F
S
V
L
Q
Y
V
V
P
E
V
K
D
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y382
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
Y404
V
R
F
N
V
L
Q
Y
V
V
P
E
V
K
D
Chicken
Gallus gallus
XP_421787
1505
177889
Y513
V
R
F
N
V
V
Q
Y
V
V
P
E
V
K
E
Frog
Xenopus laevis
A2VD00
1424
168482
H382
V
R
F
N
A
L
Q
H
V
V
P
E
V
K
E
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y382
V
R
F
N
L
L
Q
Y
V
V
P
E
V
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
L386
V
R
L
N
V
P
Q
L
V
S
E
D
F
R
N
Honey Bee
Apis mellifera
XP_397439
1143
134949
L384
V
R
L
N
I
V
N
L
A
S
P
Q
L
Q
E
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
A392
A
R
I
G
V
P
E
A
A
G
Q
T
A
K
D
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
H384
I
K
Y
N
V
V
P
H
V
I
P
Q
L
H
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
F358
R
L
S
N
L
V
N
F
S
L
D
N
K
R
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
L378
M
L
S
R
S
A
L
L
S
E
L
V
S
K
G
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
L357
R
M
Y
R
L
L
N
L
D
A
K
P
T
R
K
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
K376
H
P
L
S
I
C
Q
K
I
S
P
I
L
A
E
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
13.3
100
N.A.
93.3
100
N.A.
100
86.6
80
86.6
N.A.
40
26.6
26.6
33.3
P-Site Similarity:
100
100
40
100
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
60
66.6
33.3
86.6
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
6.6
N.A.
6.6
6.6
13.3
P-Site Similarity:
N.A.
46.6
N.A.
13.3
26.6
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
6
0
0
6
6
0
12
12
6
0
6
12
6
0
% A
% Cys:
0
0
0
0
0
6
0
0
0
0
0
0
0
0
0
% C
% Asp:
6
0
0
0
0
0
0
0
6
0
12
6
0
0
45
% D
% Glu:
0
0
0
0
0
6
6
0
0
6
6
50
0
0
34
% E
% Phe:
0
0
56
0
0
0
0
6
0
0
0
0
6
0
0
% F
% Gly:
0
0
0
6
0
0
0
0
0
6
0
0
0
0
6
% G
% His:
6
0
0
0
0
0
0
12
0
0
0
0
0
6
6
% H
% Ile:
6
0
6
0
12
0
0
0
12
6
0
6
0
0
0
% I
% Lys:
0
6
0
0
0
0
0
6
0
0
6
0
6
62
6
% K
% Leu:
0
12
17
0
23
50
6
23
0
6
6
0
17
0
0
% L
% Met:
6
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
67
0
0
17
0
0
0
0
6
0
0
6
% N
% Pro:
0
6
0
0
0
12
6
0
0
0
67
6
0
0
0
% P
% Gln:
0
0
0
6
0
0
62
0
0
0
6
12
0
6
0
% Q
% Arg:
12
67
0
12
0
0
6
0
0
0
0
0
0
23
0
% R
% Ser:
0
0
12
12
6
0
0
0
12
17
0
0
6
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
6
6
0
0
% T
% Val:
62
0
0
0
56
23
0
0
62
56
0
6
50
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
0
0
45
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _