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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3A All Species: 46.36
Human Site: Y391 Identified Species: 60
UniProt: Q14152 Number Species: 17
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14152 NP_003741.1 1382 166569 Y391 V P E V K D L Y N W L E V E F
Chimpanzee Pan troglodytes XP_001153575 1382 166541 Y391 V P E V K D L Y N W L E V E F
Rhesus Macaque Macaca mulatta XP_001102472 1228 147070 D384 V D A A R H C D L Q V R I D H
Dog Lupus familis XP_852131 1350 163016 Y391 V P E V K D L Y N W L E V E F
Cat Felis silvestris
Mouse Mus musculus P23116 1344 161918 Y391 V P E V K D L Y N W L E V E F
Rat Rattus norvegicus Q1JU68 1354 163177 Y391 V P E V K D L Y N W L E V E F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514639 1362 163866 Y413 V P E V K D L Y N W L E V E F
Chicken Gallus gallus XP_421787 1505 177889 Y522 V P E V K E L Y N W L E V D F
Frog Xenopus laevis A2VD00 1424 168482 Y391 V P E V K E L Y N W L E V D F
Zebra Danio Brachydanio rerio Q6PCR7 1267 151273 Y391 V P E V K E L Y N W L E V D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VN25 1140 133861 Y395 S E D F R N L Y N W L E V D F
Honey Bee Apis mellifera XP_397439 1143 134949 Y393 S P Q L Q E L Y S W L E V E F
Nematode Worm Caenorhab. elegans P34339 1076 124390 Y401 G Q T A K D L Y K L L E S N F
Sea Urchin Strong. purpuratus XP_798957 1284 149812 F393 I P Q L H D L F K W L E V E F
Poplar Tree Populus trichocarpa
Maize Zea mays Q9XHR2 962 111545 R367 L D N K R E N R E M P S R P Y
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LD55 987 114281 L387 E L V S K G V L S C A S Q E V
Baker's Yeast Sacchar. cerevisiae P38249 964 110326 M366 A K P T R K E M L Q S I I E D
Red Bread Mold Neurospora crassa Q7RWT1 1007 114509 G385 S P I L A E I G A D A E M Q K
Conservation
Percent
Protein Identity: 100 99.9 86.5 94.2 N.A. 93.1 93.1 N.A. 88.2 75.6 72.1 75 N.A. 41.5 42.1 31.4 45.4
Protein Similarity: 100 99.9 87.4 95.9 N.A. 95.5 95.5 N.A. 93.1 81.7 81.4 82.1 N.A. 58 58.5 48.3 62.1
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 100 86.6 86.6 86.6 N.A. 53.3 60 46.6 60
P-Site Similarity: 100 100 33.3 100 N.A. 100 100 N.A. 100 100 100 100 N.A. 80 93.3 46.6 86.6
Percent
Protein Identity: N.A. 27.2 N.A. 27.1 23.3 28.2
Protein Similarity: N.A. 43.8 N.A. 44.6 41 43.6
P-Site Identity: N.A. 0 N.A. 13.3 6.6 13.3
P-Site Similarity: N.A. 26.6 N.A. 26.6 20 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 0 6 12 6 0 0 0 6 0 12 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 6 0 0 6 0 0 0 0 0 % C
% Asp: 0 12 6 0 0 45 0 6 0 6 0 0 0 28 6 % D
% Glu: 6 6 50 0 0 34 6 0 6 0 0 78 0 56 0 % E
% Phe: 0 0 0 6 0 0 0 6 0 0 0 0 0 0 73 % F
% Gly: 6 0 0 0 0 6 0 6 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 6 6 0 0 0 0 0 0 0 0 6 % H
% Ile: 6 0 6 0 0 0 6 0 0 0 0 6 12 0 0 % I
% Lys: 0 6 0 6 62 6 0 0 12 0 0 0 0 0 6 % K
% Leu: 6 6 0 17 0 0 73 6 12 6 73 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 6 0 6 0 0 6 0 0 % M
% Asn: 0 0 6 0 0 6 6 0 56 0 0 0 0 6 0 % N
% Pro: 0 67 6 0 0 0 0 0 0 0 6 0 0 6 0 % P
% Gln: 0 6 12 0 6 0 0 0 0 12 0 0 6 6 0 % Q
% Arg: 0 0 0 0 23 0 0 6 0 0 0 6 6 0 0 % R
% Ser: 17 0 0 6 0 0 0 0 12 0 6 12 6 0 0 % S
% Thr: 0 0 6 6 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 56 0 6 50 0 0 6 0 0 0 6 0 67 0 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 67 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 67 0 0 0 0 0 0 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _