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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
54.85
Human Site:
Y447
Identified Species:
70.98
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
-0.12
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y447
L
Q
Q
V
S
Q
I
Y
Q
S
I
E
F
S
R
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y447
L
Q
Q
V
S
Q
I
Y
Q
S
I
E
F
S
R
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
L435
L
T
A
M
S
S
V
L
A
K
A
L
E
V
I
Dog
Lupus familis
XP_852131
1350
163016
Y447
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y447
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y447
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
Y469
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Chicken
Gallus gallus
XP_421787
1505
177889
Y578
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Frog
Xenopus laevis
A2VD00
1424
168482
Y447
L
Q
Q
V
A
Q
I
Y
Q
T
I
E
F
S
R
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y447
L
Q
Q
V
A
Q
I
Y
Q
S
I
E
F
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
Y450
I
R
Q
I
S
Q
V
Y
E
S
I
K
F
Q
R
Honey Bee
Apis mellifera
XP_397439
1143
134949
Y447
V
H
Q
I
S
Q
V
Y
Q
T
I
K
F
A
R
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
Y452
L
K
Q
V
S
V
I
Y
E
A
I
S
W
E
R
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
Y447
L
K
Q
V
S
E
V
Y
E
T
I
E
M
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
K418
K
V
Q
P
L
L
L
K
I
S
K
I
G
G
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
V437
S
A
P
S
L
P
E
V
Q
L
S
Q
Y
V
P
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
Y416
V
K
L
S
S
K
T
Y
F
S
Q
Y
I
A
P
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
K440
V
T
R
G
T
I
E
K
F
I
M
N
G
N
K
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
13.3
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
86.6
93.3
N.A.
53.3
53.3
53.3
60
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
80
93.3
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
13.3
N.A.
6.6
20
0
P-Site Similarity:
N.A.
26.6
N.A.
20
46.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
0
39
0
0
0
6
6
6
0
0
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
6
12
0
17
0
0
56
6
6
0
% E
% Phe:
0
0
0
0
0
0
0
0
12
0
0
0
62
0
0
% F
% Gly:
0
0
0
6
0
0
0
0
0
0
0
0
12
6
0
% G
% His:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
6
0
0
12
0
6
56
0
6
6
73
6
6
0
6
% I
% Lys:
6
17
0
0
0
6
0
12
0
6
6
12
0
0
12
% K
% Leu:
67
0
6
0
12
6
6
6
0
6
0
6
0
0
0
% L
% Met:
0
0
0
6
0
0
0
0
0
0
6
0
6
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
6
0
6
0
% N
% Pro:
0
0
6
6
0
6
0
0
0
0
0
0
0
0
12
% P
% Gln:
0
50
78
0
0
62
0
0
62
0
6
6
0
6
0
% Q
% Arg:
0
6
6
0
0
0
0
0
0
0
0
0
0
0
73
% R
% Ser:
6
0
0
12
45
6
0
0
0
62
6
6
0
56
0
% S
% Thr:
0
12
0
0
6
0
6
0
0
17
0
0
0
0
0
% T
% Val:
17
6
0
62
0
6
23
6
0
0
0
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
6
0
0
% W
% Tyr:
0
0
0
0
0
0
0
78
0
0
0
6
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _