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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3A
All Species:
33.03
Human Site:
Y499
Identified Species:
42.75
UniProt:
Q14152
Number Species:
17
Phosphosite Substitution
Charge Score:
0.12
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14152
NP_003741.1
1382
166569
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Chimpanzee
Pan troglodytes
XP_001153575
1382
166541
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Rhesus Macaque
Macaca mulatta
XP_001102472
1228
147070
R472
N
S
R
K
E
H
Q
R
I
L
A
R
R
Q
T
Dog
Lupus familis
XP_852131
1350
163016
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Cat
Felis silvestris
Mouse
Mus musculus
P23116
1344
161918
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Rat
Rattus norvegicus
Q1JU68
1354
163177
Y499
S
F
G
S
D
L
N
Y
A
T
R
E
D
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514639
1362
163866
F521
S
F
G
S
D
L
N
F
S
T
R
E
D
A
P
Chicken
Gallus gallus
XP_421787
1505
177889
Y630
S
F
G
S
D
L
N
Y
S
T
R
E
D
A
P
Frog
Xenopus laevis
A2VD00
1424
168482
Y499
S
F
G
S
D
L
N
Y
S
T
R
E
D
A
P
Zebra Danio
Brachydanio rerio
Q6PCR7
1267
151273
Y499
S
F
G
S
D
L
N
Y
S
T
K
E
D
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VN25
1140
133861
E502
Y
F
G
T
D
L
T
E
S
Q
R
E
Y
R
P
Honey Bee
Apis mellifera
XP_397439
1143
134949
E499
H
F
G
V
D
L
S
E
A
Q
R
E
D
H
P
Nematode Worm
Caenorhab. elegans
P34339
1076
124390
D510
A
T
L
A
G
G
V
D
E
C
D
N
N
E
G
Sea Urchin
Strong. purpuratus
XP_798957
1284
149812
S500
F
G
S
D
L
S
S
S
Q
Y
E
L
Q
E
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q9XHR2
962
111545
A456
T
L
R
V
L
Q
Q
A
S
C
I
F
K
S
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD55
987
114281
P475
E
S
L
S
Q
L
V
P
F
F
Q
F
S
E
V
Baker's Yeast
Sacchar. cerevisiae
P38249
964
110326
T453
S
E
L
Y
K
L
A
T
L
P
A
P
L
D
L
Red Bread Mold
Neurospora crassa
Q7RWT1
1007
114509
G482
V
H
A
G
S
S
A
G
S
A
E
S
E
T
G
Conservation
Percent
Protein Identity:
100
99.9
86.5
94.2
N.A.
93.1
93.1
N.A.
88.2
75.6
72.1
75
N.A.
41.5
42.1
31.4
45.4
Protein Similarity:
100
99.9
87.4
95.9
N.A.
95.5
95.5
N.A.
93.1
81.7
81.4
82.1
N.A.
58
58.5
48.3
62.1
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
86.6
93.3
93.3
80
N.A.
46.6
60
0
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
60
66.6
20
13.3
Percent
Protein Identity:
N.A.
27.2
N.A.
27.1
23.3
28.2
Protein Similarity:
N.A.
43.8
N.A.
44.6
41
43.6
P-Site Identity:
N.A.
0
N.A.
13.3
13.3
0
P-Site Similarity:
N.A.
20
N.A.
20
13.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
6
6
0
0
12
6
34
6
12
0
0
45
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% C
% Asp:
0
0
0
6
62
0
0
6
0
0
6
0
56
6
0
% D
% Glu:
6
6
0
0
6
0
0
12
6
0
12
62
6
17
0
% E
% Phe:
6
62
0
0
0
0
0
6
6
6
0
12
0
0
0
% F
% Gly:
0
6
62
6
6
6
0
6
0
0
0
0
0
0
12
% G
% His:
6
6
0
0
0
6
0
0
0
0
0
0
0
6
0
% H
% Ile:
0
0
0
0
0
0
0
0
6
0
6
0
0
0
6
% I
% Lys:
0
0
0
6
6
0
0
0
0
0
6
0
6
0
0
% K
% Leu:
0
6
17
0
12
73
0
0
6
6
0
6
6
0
6
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
6
0
0
0
0
0
50
0
0
0
0
6
6
0
0
% N
% Pro:
0
0
0
0
0
0
0
6
0
6
0
6
0
0
67
% P
% Gln:
0
0
0
0
6
6
12
0
6
12
6
0
6
6
0
% Q
% Arg:
0
0
12
0
0
0
0
6
0
0
56
6
6
6
0
% R
% Ser:
56
12
6
56
6
12
12
6
39
0
0
6
6
12
0
% S
% Thr:
6
6
0
6
0
0
6
6
0
50
0
0
0
6
6
% T
% Val:
6
0
0
12
0
0
12
0
0
0
0
0
0
0
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
6
0
0
6
0
0
0
45
0
6
0
0
6
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _