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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF7
All Species:
9.39
Human Site:
S599
Identified Species:
22.96
UniProt:
Q14155
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14155
NP_001106983.1
803
90012
S599
V
P
S
H
T
L
P
S
H
P
V
T
P
S
S
Chimpanzee
Pan troglodytes
XP_509742
901
100045
S676
V
P
S
H
T
L
P
S
H
A
V
T
P
S
S
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
G574
H
S
S
F
S
S
T
G
Q
P
R
G
P
L
E
Dog
Lupus familis
XP_542671
952
105982
S668
V
P
S
H
T
L
P
S
H
P
I
A
P
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9ES28
862
97037
R635
P
W
S
L
S
C
L
R
P
A
P
P
L
R
P
Rat
Rattus norvegicus
O55043
646
73122
T444
A
L
T
P
A
Y
H
T
L
P
H
P
S
H
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
A569
A
H
S
S
F
S
Y
A
G
Q
T
R
G
P
L
Chicken
Gallus gallus
Q5ZLR6
764
85889
G562
H
S
T
F
G
S
T
G
Q
I
R
G
P
L
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001116707
858
96627
P601
A
P
A
Y
H
T
L
P
H
P
S
S
H
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
G378
A
F
E
L
S
A
Q
G
L
E
K
T
K
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
54.9
73.3
N.A.
85
66.3
N.A.
57
56.5
N.A.
69.6
N.A.
N.A.
N.A.
N.A.
30.8
Protein Similarity:
100
81.9
70.8
77
N.A.
87.8
71.1
N.A.
72.9
72.7
N.A.
79.8
N.A.
N.A.
N.A.
N.A.
45.2
P-Site Identity:
100
93.3
20
86.6
N.A.
6.6
6.6
N.A.
6.6
6.6
N.A.
20
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
26.6
93.3
N.A.
13.3
20
N.A.
13.3
13.3
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
40
0
10
0
10
10
0
10
0
20
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
20
% E
% Phe:
0
10
0
20
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
10
0
0
30
10
0
0
20
10
10
0
% G
% His:
20
10
0
30
10
0
10
0
40
0
10
0
10
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
10
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% K
% Leu:
0
10
0
20
0
30
20
0
20
0
0
0
10
20
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
40
0
10
0
0
30
10
10
50
10
20
50
10
10
% P
% Gln:
0
0
0
0
0
0
10
0
20
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
20
10
0
10
0
% R
% Ser:
0
20
60
10
30
30
0
30
0
0
10
10
10
30
30
% S
% Thr:
0
0
20
0
30
10
20
10
0
0
10
30
0
0
10
% T
% Val:
30
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
10
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _