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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF7
All Species:
10
Human Site:
Y500
Identified Species:
24.44
UniProt:
Q14155
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14155
NP_001106983.1
803
90012
Y500
S
E
E
K
N
E
R
Y
L
L
L
F
P
N
V
Chimpanzee
Pan troglodytes
XP_509742
901
100045
Y577
S
E
E
K
N
E
R
Y
L
L
L
F
P
N
V
Rhesus Macaque
Macaca mulatta
XP_001083544
776
87430
L478
L
M
L
F
S
N
V
L
I
M
L
S
A
S
P
Dog
Lupus familis
XP_542671
952
105982
Y569
S
E
E
K
N
E
R
Y
L
L
L
F
P
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9ES28
862
97037
S528
H
R
N
A
F
E
I
S
G
S
M
I
E
R
I
Rat
Rattus norvegicus
O55043
646
73122
L348
G
F
I
Y
Q
G
K
L
P
T
T
G
M
T
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514136
771
86999
F472
E
E
R
Y
F
M
L
F
S
N
V
L
L
M
L
Chicken
Gallus gallus
Q5ZLR6
764
85889
F466
E
E
R
Y
F
L
L
F
S
N
V
L
L
M
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001116707
858
96627
I499
S
P
R
M
S
G
F
I
Y
Q
G
K
L
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784106
581
64090
R282
Y
C
Q
A
M
R
K
R
K
E
I
E
L
D
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.2
54.9
73.3
N.A.
85
66.3
N.A.
57
56.5
N.A.
69.6
N.A.
N.A.
N.A.
N.A.
30.8
Protein Similarity:
100
81.9
70.8
77
N.A.
87.8
71.1
N.A.
72.9
72.7
N.A.
79.8
N.A.
N.A.
N.A.
N.A.
45.2
P-Site Identity:
100
100
6.6
93.3
N.A.
6.6
0
N.A.
6.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
33.3
100
N.A.
20
13.3
N.A.
26.6
26.6
N.A.
20
N.A.
N.A.
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
0
0
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
20
50
30
0
0
40
0
0
0
10
0
10
10
0
0
% E
% Phe:
0
10
0
10
30
0
10
20
0
0
0
30
0
0
0
% F
% Gly:
10
0
0
0
0
20
0
0
10
0
10
10
0
0
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
10
10
10
0
10
10
0
0
40
% I
% Lys:
0
0
0
30
0
0
20
0
10
0
0
10
0
0
0
% K
% Leu:
10
0
10
0
0
10
20
20
30
30
40
20
40
0
30
% L
% Met:
0
10
0
10
10
10
0
0
0
10
10
0
10
20
0
% M
% Asn:
0
0
10
0
30
10
0
0
0
20
0
0
0
30
0
% N
% Pro:
0
10
0
0
0
0
0
0
10
0
0
0
30
10
10
% P
% Gln:
0
0
10
0
10
0
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
10
30
0
0
10
30
10
0
0
0
0
0
10
0
% R
% Ser:
40
0
0
0
20
0
0
10
20
10
0
10
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
10
10
0
0
10
0
% T
% Val:
0
0
0
0
0
0
10
0
0
0
20
0
0
0
20
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
30
0
0
0
30
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _