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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTLL12 All Species: 23.94
Human Site: S268 Identified Species: 37.62
UniProt: Q14166 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14166 NP_055955.1 644 74404 S268 P T D M L D L S S C T P E P P
Chimpanzee Pan troglodytes XP_001171890 644 74373 S268 P T D M L D L S S C T P E P P
Rhesus Macaque Macaca mulatta XP_001104848 751 85695 S375 P T D M L D L S S C T P E P P
Dog Lupus familis XP_531703 642 73878 S266 P A D M L D F S S S T P E P P
Cat Felis silvestris
Mouse Mus musculus Q3UDE2 639 74025 S263 P A D M L D L S F S T P E P P
Rat Rattus norvegicus NP_001129394 639 73879 S263 P A D M L D L S S S T P E P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518003 446 51715 E133 Q L N Q G S A E E Q V P V W Y
Chicken Gallus gallus NP_001012558 627 72851 N251 P N E V L D V N C F T P E P S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_956546 625 73192 S249 P E E L D A V S D D V Q E P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610325 626 72528 E239 R D A D L T G E S F L Q V E P
Honey Bee Apis mellifera XP_394564 616 72647 E232 I E T S F L G E S F A Q V E P
Nematode Worm Caenorhab. elegans Q09512 662 76732 S281 P W A A Q D F S K E T M I P D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002326123 868 98864 P496 L T A Y F H T P Q Y Y F I Q E
Maize Zea mays NP_001151803 872 99229 P496 L T A W F R T P E N Y F I Q E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177879 855 97525 P484 L T A W F Q T P E N Y F I H E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 83.8 87.2 N.A. 85.5 85 N.A. 50.7 75 N.A. 62.4 N.A. 40.3 46.2 32.1 N.A.
Protein Similarity: 100 99.3 85.3 92.6 N.A. 90.9 91.1 N.A. 58.7 85.7 N.A. 77.6 N.A. 59.1 63.8 49.5 N.A.
P-Site Identity: 100 100 100 80 N.A. 80 86.6 N.A. 6.6 46.6 N.A. 26.6 N.A. 20 13.3 33.3 N.A.
P-Site Similarity: 100 100 100 80 N.A. 80 86.6 N.A. 13.3 73.3 N.A. 46.6 N.A. 20 13.3 33.3 N.A.
Percent
Protein Identity: 28 28.1 N.A. 27.8 N.A. N.A.
Protein Similarity: 41.2 41.1 N.A. 42.8 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 6.6 N.A. N.A.
P-Site Similarity: 6.6 6.6 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 34 7 0 7 7 0 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 20 0 0 0 0 0 % C
% Asp: 0 7 40 7 7 54 0 0 7 7 0 0 0 0 7 % D
% Glu: 0 14 14 0 0 0 0 20 20 7 0 0 54 14 20 % E
% Phe: 0 0 0 0 27 0 14 0 7 20 0 20 0 0 0 % F
% Gly: 0 0 0 0 7 0 14 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 0 0 27 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % K
% Leu: 20 7 0 7 54 7 34 0 0 0 7 0 0 0 0 % L
% Met: 0 0 0 40 0 0 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 7 7 0 0 0 0 7 0 14 0 0 0 0 0 % N
% Pro: 60 0 0 0 0 0 0 20 0 0 0 54 0 60 54 % P
% Gln: 7 0 0 7 7 7 0 0 7 7 0 20 0 14 0 % Q
% Arg: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 7 0 7 0 54 47 20 0 0 0 0 14 % S
% Thr: 0 40 7 0 0 7 20 0 0 0 54 0 0 0 0 % T
% Val: 0 0 0 7 0 0 14 0 0 0 14 0 20 0 0 % V
% Trp: 0 7 0 14 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 7 20 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _