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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTLL12
All Species:
47.58
Human Site:
Y508
Identified Species:
74.76
UniProt:
Q14166
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14166
NP_055955.1
644
74404
Y508
A
L
N
D
L
D
D
Y
E
K
H
F
T
V
M
Chimpanzee
Pan troglodytes
XP_001171890
644
74373
Y508
A
L
N
D
L
D
D
Y
E
K
H
F
T
V
M
Rhesus Macaque
Macaca mulatta
XP_001104848
751
85695
Y615
A
L
N
D
L
D
D
Y
E
K
H
F
T
V
M
Dog
Lupus familis
XP_531703
642
73878
Y506
A
L
D
D
L
D
D
Y
E
K
H
F
T
V
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3UDE2
639
74025
Y503
A
L
D
D
L
D
D
Y
E
K
H
F
T
V
M
Rat
Rattus norvegicus
NP_001129394
639
73879
Y503
A
L
N
D
L
D
D
Y
E
K
H
F
T
V
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518003
446
51715
T343
P
R
T
F
N
L
R
T
E
L
P
Q
F
I
S
Chicken
Gallus gallus
NP_001012558
627
72851
Y491
S
L
D
D
L
D
D
Y
E
K
H
F
T
V
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956546
625
73192
Y489
S
L
D
H
F
D
D
Y
Q
K
H
Y
T
V
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610325
626
72528
Y489
T
L
D
H
F
D
D
Y
E
K
H
Y
T
V
M
Honey Bee
Apis mellifera
XP_394564
616
72647
Y482
A
L
N
N
F
D
V
Y
E
Q
H
F
T
V
M
Nematode Worm
Caenorhab. elegans
Q09512
662
76732
V531
S
L
S
N
F
E
D
V
E
T
H
F
T
V
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002326123
868
98864
Y736
D
K
H
S
L
F
E
Y
E
T
H
F
T
V
M
Maize
Zea mays
NP_001151803
872
99229
Y740
E
K
T
S
F
F
E
Y
E
T
H
F
T
V
M
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177879
855
97525
Y724
E
K
H
S
F
F
E
Y
E
T
H
F
T
V
M
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
83.8
87.2
N.A.
85.5
85
N.A.
50.7
75
N.A.
62.4
N.A.
40.3
46.2
32.1
N.A.
Protein Similarity:
100
99.3
85.3
92.6
N.A.
90.9
91.1
N.A.
58.7
85.7
N.A.
77.6
N.A.
59.1
63.8
49.5
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
6.6
86.6
N.A.
60
N.A.
66.6
73.3
46.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
100
N.A.
86.6
N.A.
80
86.6
73.3
N.A.
Percent
Protein Identity:
28
28.1
N.A.
27.8
N.A.
N.A.
Protein Similarity:
41.2
41.1
N.A.
42.8
N.A.
N.A.
P-Site Identity:
53.3
46.6
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
66.6
53.3
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
34
47
0
67
67
0
0
0
0
0
0
0
0
% D
% Glu:
14
0
0
0
0
7
20
0
94
0
0
0
0
0
0
% E
% Phe:
0
0
0
7
40
20
0
0
0
0
0
80
7
0
7
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
14
14
0
0
0
0
0
0
94
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
20
0
0
0
0
0
0
0
60
0
0
0
0
0
% K
% Leu:
0
74
0
0
54
7
0
0
0
7
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
87
% M
% Asn:
0
0
34
14
7
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
7
0
7
0
0
0
% Q
% Arg:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% R
% Ser:
20
0
7
20
0
0
0
0
0
0
0
0
0
0
7
% S
% Thr:
7
0
14
0
0
0
0
7
0
27
0
0
94
0
0
% T
% Val:
0
0
0
0
0
0
7
7
0
0
0
0
0
94
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
87
0
0
0
14
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _