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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MPP2 All Species: 33.33
Human Site: Y243 Identified Species: 52.38
UniProt: Q14168 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14168 NP_005365.3 576 64581 Y243 I L K I L P S Y Q E P H L P R
Chimpanzee Pan troglodytes XP_511538 656 72549 Y323 I L K I L P S Y Q E P H L P R
Rhesus Macaque Macaca mulatta XP_001096776 582 65885 Y251 T L K I L P S Y R D T I T P Q
Dog Lupus familis XP_548068 552 61535 Y219 I L K I L P S Y Q E P H L P R
Cat Felis silvestris
Mouse Mus musculus Q9WV34 552 61537 Y219 I L K I L P S Y Q E P H L P R
Rat Rattus norvegicus Q62915 909 103240 Y571 T F K I V P S Y R T Q S S S C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507958 540 61012 Y209 T L K I L P S Y R D T I T P Q
Chicken Gallus gallus Q5ZJ00 468 52501 P173 R A Q F D Y D P K K D N L I P
Frog Xenopus laevis NP_001087762 532 59489 Y199 V L K I L P S Y Q E Q H P L R
Zebra Danio Brachydanio rerio Q6P0D7 576 65174 I220 T F K V V P G I K D E A Q S K
Tiger Blowfish Takifugu rubipres P49697 467 52590 D172 M R G Q F D Y D P A M D D L I
Fruit Fly Dros. melanogaster Q24210 898 100893 Y576 T F K I V P S Y R S A P P P C
Honey Bee Apis mellifera XP_391909 602 67965 I265 S L K L A P G I E K N T Y F P
Nematode Worm Caenorhab. elegans P54936 961 108794 Y627 T F K I I P S Y R S A P P A C
Sea Urchin Strong. purpuratus XP_791632 556 63023 Y223 T L K I R P S Y Q D C I M L P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.5 66.3 93.4 N.A. 93.4 30.2 N.A. 66.1 36.2 72 36.8 33.5 31.9 42.3 26.9 46
Protein Similarity: 100 82.9 81.7 94.7 N.A. 94.9 43.5 N.A. 80.5 53.1 82.1 55 51.3 43.7 61.9 41.7 65.8
P-Site Identity: 100 100 53.3 100 N.A. 100 33.3 N.A. 53.3 6.6 73.3 13.3 0 40 20 33.3 46.6
P-Site Similarity: 100 100 73.3 100 N.A. 100 46.6 N.A. 73.3 33.3 80 46.6 6.6 53.3 40 46.6 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 7 0 0 0 0 7 14 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 20 % C
% Asp: 0 0 0 0 7 7 7 7 0 27 7 7 7 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 7 34 7 0 0 0 0 % E
% Phe: 0 27 0 7 7 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 7 0 0 0 14 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 34 0 0 0 % H
% Ile: 27 0 0 74 7 0 0 14 0 0 0 20 0 7 7 % I
% Lys: 0 0 87 0 0 0 0 0 14 14 0 0 0 0 7 % K
% Leu: 0 60 0 7 47 0 0 0 0 0 0 0 34 20 0 % L
% Met: 7 0 0 0 0 0 0 0 0 0 7 0 7 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 0 % N
% Pro: 0 0 0 0 0 87 0 7 7 0 27 14 20 47 20 % P
% Gln: 0 0 7 7 0 0 0 0 40 0 14 0 7 0 14 % Q
% Arg: 7 7 0 0 7 0 0 0 34 0 0 0 0 0 34 % R
% Ser: 7 0 0 0 0 0 74 0 0 14 0 7 7 14 0 % S
% Thr: 47 0 0 0 0 0 0 0 0 7 14 7 14 0 0 % T
% Val: 7 0 0 7 20 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 7 74 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _