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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLA2 All Species: 22.73
Human Site: S165 Identified Species: 35.71
UniProt: Q14181 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14181 NP_002680.2 598 65948 S165 S Q K Y N S R S N R G E V V T
Chimpanzee Pan troglodytes XP_508549 598 65915 S165 S Q K Y N S R S N R G E V V T
Rhesus Macaque Macaca mulatta XP_001113977 598 65971 S165 S Q K Y N S R S N R G E V V T
Dog Lupus familis XP_533234 595 65743 N161 S Q K Y S S R N N R G E V V I
Cat Felis silvestris
Mouse Mus musculus P33611 600 66249 T165 S Q K Y T S R T N R G E V V T
Rat Rattus norvegicus O89043 600 66618 T165 S Q K Y S S R T N R G E V V T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519697 439 48232 S34 L F S P T S F S P S A T P S Q
Chicken Gallus gallus
Frog Xenopus laevis NP_001086972 598 66827 T165 S Q K Y G S R T N R G E V V T
Zebra Danio Brachydanio rerio NP_955875 599 66656 G165 S Q K Y G M R G G R G E V V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VB62 609 66952 G188 G H P K L L A G S S W Q S Q M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q21625 581 64085 A150 N E K F L K R A D P S H V V T
Sea Urchin Strong. purpuratus XP_780208 604 66528 K171 Q K Y S S R S K S G E V V A S
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001130410 626 69135 A171 T Q Q Y V L N A D N A V G V P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_176930 620 69024 A166 K F N V G N V A A H A E N G N
Baker's Yeast Sacchar. cerevisiae P38121 705 78756 N218 N I E I S S G N P N V G L L S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 98.1 88.1 N.A. 83 84.3 N.A. 57.8 N.A. 64.8 57.4 N.A. 29.8 N.A. 25.5 43.3
Protein Similarity: 100 100 98.4 93.8 N.A. 90.1 91 N.A. 66.7 N.A. 80 75.2 N.A. 49.4 N.A. 47.6 62.9
P-Site Identity: 100 100 100 80 N.A. 86.6 86.6 N.A. 13.3 N.A. 86.6 66.6 N.A. 0 N.A. 33.3 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 100 N.A. 13.3 N.A. 93.3 73.3 N.A. 13.3 N.A. 66.6 33.3
Percent
Protein Identity: N.A. 28.5 N.A. 30.3 25.1 N.A.
Protein Similarity: N.A. 47.4 N.A. 50 43.4 N.A.
P-Site Identity: N.A. 20 N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. 46.6 N.A. 20 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 20 7 0 20 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 % D
% Glu: 0 7 7 0 0 0 0 0 0 0 7 60 0 0 0 % E
% Phe: 0 14 0 7 0 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 20 0 7 14 7 7 54 7 7 7 0 % G
% His: 0 7 0 0 0 0 0 0 0 7 0 7 0 0 0 % H
% Ile: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 7 % I
% Lys: 7 7 60 7 0 7 0 7 0 0 0 0 0 0 0 % K
% Leu: 7 0 0 0 14 14 0 0 0 0 0 0 7 7 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % M
% Asn: 14 0 7 0 20 7 7 14 47 14 0 0 7 0 7 % N
% Pro: 0 0 7 7 0 0 0 0 14 7 0 0 7 0 7 % P
% Gln: 7 60 7 0 0 0 0 0 0 0 0 7 0 7 7 % Q
% Arg: 0 0 0 0 0 7 60 0 0 54 0 0 0 0 0 % R
% Ser: 54 0 7 7 27 60 7 27 14 14 7 0 7 7 20 % S
% Thr: 7 0 0 0 14 0 0 20 0 0 0 7 0 0 47 % T
% Val: 0 0 0 7 7 0 7 0 0 0 7 14 67 67 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % W
% Tyr: 0 0 7 60 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _