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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WRN All Species: 4.55
Human Site: T743 Identified Species: 9.09
UniProt: Q14191 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14191 NP_000544.2 1432 162495 T743 Y L E V R R K T G N I L Q D L
Chimpanzee Pan troglodytes XP_528104 1432 162383 T743 Y L E V R R K T G N I L Q D L
Rhesus Macaque Macaca mulatta XP_001085031 1432 162219 G743 L E V R R K T G N I L Q D L Q
Dog Lupus familis XP_539984 1680 188955 G940 L E V R R K T G S I L Q D L D
Cat Felis silvestris
Mouse Mus musculus O09053 1401 157269 G708 L E V G R K T G N I L Q D L K
Rat Rattus norvegicus XP_001059940 1400 157256 G708 L E V E R K T G N I L Q D L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508312 1813 203868 G1098 L E V G R K T G N V L Q D L K
Chicken Gallus gallus Q9I920 1142 126164 K491 S K K D P I I K L L Y V T P E
Frog Xenopus laevis O93530 1436 161833 N686 D V A R K T T N I S I D L R Q
Zebra Danio Brachydanio rerio XP_697980 1361 152386 G639 L D V N R K S G D V I Q D L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q19546 1056 118504 P405 A N L R L R K P L I T T T S F
Sea Urchin Strong. purpuratus XP_001184484 1274 143807 G623 L T V I S S P G P E P H E S V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 94.1 64.5 N.A. 70.2 69.5 N.A. 41.7 22.9 52.1 45.8 N.A. N.A. N.A. 25.4 20.3
Protein Similarity: 100 99.3 97.2 72.6 N.A. 81.8 81.2 N.A. 56.5 38.3 70 63.7 N.A. N.A. N.A. 41.8 38.8
P-Site Identity: 100 100 6.6 6.6 N.A. 6.6 6.6 N.A. 6.6 0 6.6 13.3 N.A. N.A. N.A. 13.3 0
P-Site Similarity: 100 100 20 20 N.A. 20 20 N.A. 20 13.3 26.6 20 N.A. N.A. N.A. 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 0 9 0 0 0 0 9 0 0 9 50 17 9 % D
% Glu: 0 42 17 9 0 0 0 0 0 9 0 0 9 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 17 0 0 0 59 17 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 0 0 0 9 0 9 9 0 9 42 34 0 0 0 0 % I
% Lys: 0 9 9 0 9 50 25 9 0 0 0 0 0 0 34 % K
% Leu: 59 17 9 0 9 0 0 0 17 9 42 17 9 50 17 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 9 0 9 0 0 0 9 34 17 0 0 0 0 0 % N
% Pro: 0 0 0 0 9 0 9 9 9 0 9 0 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 50 17 0 17 % Q
% Arg: 0 0 0 34 67 25 0 0 0 0 0 0 0 9 0 % R
% Ser: 9 0 0 0 9 9 9 0 9 9 0 0 0 17 0 % S
% Thr: 0 9 0 0 0 9 50 17 0 0 9 9 17 0 0 % T
% Val: 0 9 59 17 0 0 0 0 0 17 0 9 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 17 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _