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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ICT1
All Species:
28.48
Human Site:
S137
Identified Species:
44.76
UniProt:
Q14197
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14197
NP_001536.1
206
23630
S137
L
G
E
L
I
L
T
S
E
S
S
R
Y
Q
F
Chimpanzee
Pan troglodytes
XP_001138419
206
23643
S137
L
G
E
L
I
L
T
S
E
S
S
R
Y
Q
F
Rhesus Macaque
Macaca mulatta
XP_001092083
206
23638
S137
L
G
E
L
I
L
T
S
E
S
S
R
Y
Q
F
Dog
Lupus familis
XP_533118
161
18501
L106
F
R
N
L
A
D
C
L
Q
K
I
R
D
M
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8R035
206
23458
S137
A
G
E
L
V
L
T
S
E
S
S
R
Y
Q
F
Rat
Rattus norvegicus
XP_221110
206
23451
S137
A
G
E
L
V
L
T
S
E
S
S
R
Y
Q
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516100
144
16353
C88
Q
L
R
N
L
A
E
C
L
Q
K
I
R
D
I
Chicken
Gallus gallus
XP_420117
194
21944
E127
E
L
I
V
N
S
E
E
S
R
Y
Q
M
R
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922710
193
21697
Q130
R
S
E
I
S
R
S
Q
R
R
N
L
Q
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609416
203
22777
S130
D
G
Y
F
Y
I
K
S
D
L
T
R
S
Q
Q
Honey Bee
Apis mellifera
XP_393856
198
22969
S128
E
G
Y
L
I
I
K
S
E
L
T
R
S
Q
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001179942
139
15641
Q83
A
E
W
L
P
Q
N
Q
K
N
K
I
N
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001148646
227
24898
S156
D
G
E
L
V
I
S
S
T
K
T
R
T
Q
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001077760
236
26053
S164
D
G
E
L
V
I
S
S
T
K
T
R
T
Q
K
Baker's Yeast
Sacchar. cerevisiae
Q12322
202
23171
I129
K
G
S
D
S
I
V
I
Q
S
D
E
T
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.1
64.5
N.A.
79.6
80
N.A.
50
59.7
N.A.
42.2
N.A.
38.3
37.3
N.A.
33
Protein Similarity:
100
99.5
96.5
71.8
N.A.
88.8
89.3
N.A.
61.6
71.3
N.A.
59.7
N.A.
56.3
56.3
N.A.
43.6
P-Site Identity:
100
100
100
13.3
N.A.
86.6
86.6
N.A.
0
0
N.A.
6.6
N.A.
26.6
46.6
N.A.
6.6
P-Site Similarity:
100
100
100
20
N.A.
93.3
93.3
N.A.
6.6
20
N.A.
33.3
N.A.
46.6
60
N.A.
20
Percent
Protein Identity:
N.A.
33
N.A.
30
27.6
N.A.
Protein Similarity:
N.A.
49.7
N.A.
51.6
49.5
N.A.
P-Site Identity:
N.A.
40
N.A.
40
13.3
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
66.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
7
% C
% Asp:
20
0
0
7
0
7
0
0
7
0
7
0
7
7
0
% D
% Glu:
14
7
54
0
0
0
14
7
40
0
0
7
0
7
0
% E
% Phe:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
34
% F
% Gly:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
7
27
34
0
7
0
0
7
14
0
0
14
% I
% Lys:
7
0
0
0
0
0
14
0
7
20
14
0
0
0
14
% K
% Leu:
20
14
0
67
7
34
0
7
7
14
0
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
7
0
% M
% Asn:
0
0
7
7
7
0
7
0
0
7
7
0
7
0
7
% N
% Pro:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
0
7
0
14
14
7
0
7
7
60
14
% Q
% Arg:
7
7
7
0
0
7
0
0
7
14
0
67
7
14
7
% R
% Ser:
0
7
7
0
14
7
20
60
7
40
34
0
14
7
7
% S
% Thr:
0
0
0
0
0
0
34
0
14
0
27
0
20
0
0
% T
% Val:
0
0
0
7
27
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
14
0
7
0
0
0
0
0
7
0
34
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _