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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICT1 All Species: 22.42
Human Site: T107 Identified Species: 35.24
UniProt: Q14197 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14197 NP_001536.1 206 23630 T107 E V R F H L A T A E W I A E P
Chimpanzee Pan troglodytes XP_001138419 206 23643 T107 E V R F H L A T A E W I A E P
Rhesus Macaque Macaca mulatta XP_001092083 206 23638 T107 E V R F H L A T A D W I A E P
Dog Lupus familis XP_533118 161 18501 I76 P V R Q K I A I T H R N K I N
Cat Felis silvestris
Mouse Mus musculus Q8R035 206 23458 S107 E V R F H L A S A D W I E E P
Rat Rattus norvegicus XP_221110 206 23451 S107 E V R F H L A S A D W I A E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516100 144 16353 A58 E P L R Q K I A I E Q R N R I
Chicken Gallus gallus XP_420117 194 21944 D97 R F H L A S A D W I P E A V R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922710 193 21697 E100 Q T A D W L P E T L K S Q I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609416 203 22777 Q100 D V R F K V A Q A D W I P E Q
Honey Bee Apis mellifera XP_393856 198 22969 S98 D I R F H L Q S A K W L S E E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001179942 139 15641 G53 L V K Y S R S G G A G G Q N V
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001148646 227 24898 E126 D M R F N V K E A H W L G E R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001077760 236 26053 N134 D M R F N V K N A Y W L S D R
Baker's Yeast Sacchar. cerevisiae Q12322 202 23171 S99 T L T L S G L S N C A W I P Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.1 64.5 N.A. 79.6 80 N.A. 50 59.7 N.A. 42.2 N.A. 38.3 37.3 N.A. 33
Protein Similarity: 100 99.5 96.5 71.8 N.A. 88.8 89.3 N.A. 61.6 71.3 N.A. 59.7 N.A. 56.3 56.3 N.A. 43.6
P-Site Identity: 100 100 93.3 20 N.A. 80 86.6 N.A. 13.3 13.3 N.A. 6.6 N.A. 53.3 46.6 N.A. 6.6
P-Site Similarity: 100 100 100 26.6 N.A. 93.3 100 N.A. 13.3 13.3 N.A. 13.3 N.A. 73.3 86.6 N.A. 26.6
Percent
Protein Identity: N.A. 33 N.A. 30 27.6 N.A.
Protein Similarity: N.A. 49.7 N.A. 51.6 49.5 N.A.
P-Site Identity: N.A. 33.3 N.A. 26.6 0 N.A.
P-Site Similarity: N.A. 66.6 N.A. 73.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 0 54 7 60 7 7 0 34 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 27 0 0 7 0 0 0 7 0 27 0 0 0 7 0 % D
% Glu: 40 0 0 0 0 0 0 14 0 20 0 7 7 54 7 % E
% Phe: 0 7 0 60 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 7 0 7 7 0 7 7 7 0 0 % G
% His: 0 0 7 0 40 0 0 0 0 14 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 7 7 7 7 7 0 40 7 14 7 % I
% Lys: 0 0 7 0 14 7 14 0 0 7 7 0 7 0 0 % K
% Leu: 7 7 7 14 0 47 7 0 0 7 0 20 0 0 7 % L
% Met: 0 14 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 14 0 0 7 7 0 0 7 7 7 7 % N
% Pro: 7 7 0 0 0 0 7 0 0 0 7 0 7 7 34 % P
% Gln: 7 0 0 7 7 0 7 7 0 0 7 0 14 0 14 % Q
% Arg: 7 0 67 7 0 7 0 0 0 0 7 7 0 7 20 % R
% Ser: 0 0 0 0 14 7 7 27 0 0 0 7 14 0 0 % S
% Thr: 7 7 7 0 0 0 0 20 14 0 0 0 0 0 0 % T
% Val: 0 54 0 0 0 20 0 0 0 0 0 0 0 7 7 % V
% Trp: 0 0 0 0 7 0 0 0 7 0 60 7 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _