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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICT1 All Species: 23.64
Human Site: T37 Identified Species: 37.14
UniProt: Q14197 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14197 NP_001536.1 206 23630 T37 L H K Q K D G T E F K S I Y S
Chimpanzee Pan troglodytes XP_001138419 206 23643 T37 L H K Q K D G T E F K S I Y S
Rhesus Macaque Macaca mulatta XP_001092083 206 23638 T37 L H K Q K D G T E F K S I Y S
Dog Lupus familis XP_533118 161 18501
Cat Felis silvestris
Mouse Mus musculus Q8R035 206 23458 T37 L H R Q V D G T T F Q S I Y S
Rat Rattus norvegicus XP_221110 206 23451 T37 L H R Q V N G T E F K S I Y S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516100 144 16353
Chicken Gallus gallus XP_420117 194 21944 S27 S Q R A A T G S E F R S A Y S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922710 193 21697 T30 I T A L S S G T A G I Q H R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609416 203 22777 S30 N L L G R Q L S Y K S D L S L
Honey Bee Apis mellifera XP_393856 198 22969 Y28 I F G K A F T Y K S A Y S L D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001179942 139 15641
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001148646 227 24898 D56 C S A A G A G D A G G K K V S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001077760 236 26053 S64 A A S T S G G S G G D R K V S
Baker's Yeast Sacchar. cerevisiae Q12322 202 23171 Q29 M L H C K K Q Q F V E E A V R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.1 64.5 N.A. 79.6 80 N.A. 50 59.7 N.A. 42.2 N.A. 38.3 37.3 N.A. 33
Protein Similarity: 100 99.5 96.5 71.8 N.A. 88.8 89.3 N.A. 61.6 71.3 N.A. 59.7 N.A. 56.3 56.3 N.A. 43.6
P-Site Identity: 100 100 100 0 N.A. 73.3 80 N.A. 0 40 N.A. 13.3 N.A. 0 0 N.A. 0
P-Site Similarity: 100 100 100 0 N.A. 86.6 93.3 N.A. 0 60 N.A. 20 N.A. 20 20 N.A. 0
Percent
Protein Identity: N.A. 33 N.A. 30 27.6 N.A.
Protein Similarity: N.A. 49.7 N.A. 51.6 49.5 N.A.
P-Site Identity: N.A. 13.3 N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 14 14 14 7 0 0 14 0 7 0 14 0 0 % A
% Cys: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 27 0 7 0 0 7 7 0 0 7 % D
% Glu: 0 0 0 0 0 0 0 0 34 0 7 7 0 0 0 % E
% Phe: 0 7 0 0 0 7 0 0 7 40 0 0 0 0 0 % F
% Gly: 0 0 7 7 7 7 60 0 7 20 7 0 0 0 0 % G
% His: 0 34 7 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 14 0 0 0 0 0 0 0 0 0 7 0 34 0 0 % I
% Lys: 0 0 20 7 27 7 0 0 7 7 27 7 14 0 0 % K
% Leu: 34 14 7 7 0 0 7 0 0 0 0 0 7 7 7 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % P
% Gln: 0 7 0 34 0 7 7 7 0 0 7 7 0 0 0 % Q
% Arg: 0 0 20 0 7 0 0 0 0 0 7 7 0 7 7 % R
% Ser: 7 7 7 0 14 7 0 20 0 7 7 40 7 7 54 % S
% Thr: 0 7 0 7 0 7 7 40 7 0 0 0 0 0 0 % T
% Val: 0 0 0 0 14 0 0 0 0 7 0 0 0 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 7 7 0 0 7 0 40 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _