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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ICT1 All Species: 19.7
Human Site: T57 Identified Species: 30.95
UniProt: Q14197 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14197 NP_001536.1 206 23630 T57 P E S Q G S D T A W R V P N G
Chimpanzee Pan troglodytes XP_001138419 206 23643 T57 P E S Q G S D T A W R V P D G
Rhesus Macaque Macaca mulatta XP_001092083 206 23638 T57 P E F Q G S D T A W R V P D G
Dog Lupus familis XP_533118 161 18501 D26 D A K Q A N N D I P L D R L T
Cat Felis silvestris
Mouse Mus musculus Q8R035 206 23458 T57 P E S K G A D T A W K V P E H
Rat Rattus norvegicus XP_221110 206 23451 T57 P E S K G V D T A W K V P E H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516100 144 16353 T8 D S A V Q A S T D I P L D R L
Chicken Gallus gallus XP_420117 194 21944 A47 P P R D G G T A S D P E E A K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001922710 193 21697 S50 P A R A A A R S T Q D Q Q L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609416 203 22777 T50 G A R L Q I Y T P P P P P S G
Honey Bee Apis mellifera XP_393856 198 22969 P48 H S I K L F T P T F V P E D P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001179942 139 15641
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001148646 227 24898 A76 T Q Q V L R N A E E R A A S A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001077760 236 26053 A84 V Q Q M L H E A E E R A S S A
Baker's Yeast Sacchar. cerevisiae Q12322 202 23171 F49 K I G K K S D F V Q A R N W V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.1 64.5 N.A. 79.6 80 N.A. 50 59.7 N.A. 42.2 N.A. 38.3 37.3 N.A. 33
Protein Similarity: 100 99.5 96.5 71.8 N.A. 88.8 89.3 N.A. 61.6 71.3 N.A. 59.7 N.A. 56.3 56.3 N.A. 43.6
P-Site Identity: 100 93.3 86.6 6.6 N.A. 66.6 66.6 N.A. 6.6 13.3 N.A. 6.6 N.A. 20 0 N.A. 0
P-Site Similarity: 100 100 93.3 20 N.A. 86.6 80 N.A. 26.6 20 N.A. 20 N.A. 26.6 20 N.A. 0
Percent
Protein Identity: N.A. 33 N.A. 30 27.6 N.A.
Protein Similarity: N.A. 49.7 N.A. 51.6 49.5 N.A.
P-Site Identity: N.A. 6.6 N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. 26.6 N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 20 7 7 14 20 0 20 34 0 7 14 7 7 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 0 0 7 0 0 40 7 7 7 7 7 7 20 0 % D
% Glu: 0 34 0 0 0 0 7 0 14 14 0 7 14 14 0 % E
% Phe: 0 0 7 0 0 7 0 7 0 7 0 0 0 0 0 % F
% Gly: 7 0 7 0 40 7 0 0 0 0 0 0 0 0 27 % G
% His: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 14 % H
% Ile: 0 7 7 0 0 7 0 0 7 7 0 0 0 0 0 % I
% Lys: 7 0 7 27 7 0 0 0 0 0 14 0 0 0 7 % K
% Leu: 0 0 0 7 20 0 0 0 0 0 7 7 0 14 7 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 7 14 0 0 0 0 0 7 7 0 % N
% Pro: 47 7 0 0 0 0 0 7 7 14 20 14 40 0 7 % P
% Gln: 0 14 14 27 14 0 0 0 0 14 0 7 7 0 0 % Q
% Arg: 0 0 20 0 0 7 7 0 0 0 34 7 7 7 0 % R
% Ser: 0 14 27 0 0 27 7 7 7 0 0 0 7 20 0 % S
% Thr: 7 0 0 0 0 0 14 47 14 0 0 0 0 0 14 % T
% Val: 7 0 0 14 0 7 0 0 7 0 7 34 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 34 0 0 0 7 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _