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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B1
All Species:
21.82
Human Site:
S12
Identified Species:
40
UniProt:
Q14232
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14232
NP_001405.1
305
33712
S12
E
L
I
E
Y
F
K
S
Q
M
K
E
D
P
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101480
305
33696
S12
E
L
I
E
Y
F
K
S
Q
M
K
E
D
P
D
Dog
Lupus familis
XP_534645
305
33854
S12
E
L
I
E
Y
F
K
S
Q
M
K
E
D
P
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99LC8
305
33798
S12
E
L
I
E
Y
F
K
S
Q
M
K
G
D
P
K
Rat
Rattus norvegicus
Q64270
305
33660
S12
E
L
I
K
Y
F
K
S
Q
M
K
G
D
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507558
316
34903
S23
E
L
I
E
Y
F
K
S
Q
M
K
E
D
P
D
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084600
302
33557
C12
E
I
L
Q
Y
F
K
C
Q
L
Q
E
D
T
N
Zebra Danio
Brachydanio rerio
XP_002662251
302
33553
G12
E
L
V
E
Y
F
R
G
Q
I
R
E
D
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651752
306
34376
Q19
D
V
V
K
Y
F
L
Q
L
L
D
E
D
K
D
Honey Bee
Apis mellifera
XP_392643
301
33602
D12
E
I
C
Q
Y
F
N
D
I
I
K
D
E
K
D
Nematode Worm
Caenorhab. elegans
P34604
305
34099
G12
S
I
I
S
S
F
R
G
K
L
E
N
D
P
S
Sea Urchin
Strong. purpuratus
XP_783380
304
33798
E12
D
A
I
R
Y
F
T
E
Y
M
S
T
N
Q
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P14741
305
34007
F13
I
T
E
T
Y
L
R
F
L
E
E
D
T
E
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.3
96.3
N.A.
94
92.7
N.A.
88.2
N.A.
78
76.3
N.A.
49.6
53.4
43.2
59.3
Protein Similarity:
100
N.A.
99.3
97.3
N.A.
96.7
95
N.A.
92.7
N.A.
88.5
87.2
N.A.
67.6
75.7
63.9
75.7
P-Site Identity:
100
N.A.
100
100
N.A.
86.6
80
N.A.
100
N.A.
46.6
66.6
N.A.
33.3
33.3
26.6
33.3
P-Site Similarity:
100
N.A.
100
100
N.A.
86.6
93.3
N.A.
100
N.A.
86.6
93.3
N.A.
66.6
66.6
60
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
16
0
0
0
0
0
0
8
0
0
8
16
77
0
62
% D
% Glu:
70
0
8
47
0
0
0
8
0
8
16
54
8
8
0
% E
% Phe:
0
0
0
0
0
93
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
16
0
0
0
16
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
24
62
0
0
0
0
0
8
16
0
0
0
0
0
% I
% Lys:
0
0
0
16
0
0
54
0
8
0
54
0
0
16
8
% K
% Leu:
0
54
8
0
0
8
8
0
16
24
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
8
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
8
8
0
16
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
62
0
% P
% Gln:
0
0
0
16
0
0
0
8
62
0
8
0
0
8
0
% Q
% Arg:
0
0
0
8
0
0
24
0
0
0
8
0
0
0
0
% R
% Ser:
8
0
0
8
8
0
0
47
0
0
8
0
0
0
8
% S
% Thr:
0
8
0
8
0
0
8
0
0
0
0
8
8
8
0
% T
% Val:
0
8
16
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
93
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _