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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B1
All Species:
27.88
Human Site:
S80
Identified Species:
51.11
UniProt:
Q14232
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14232
NP_001405.1
305
33712
S80
L
R
F
I
S
L
A
S
L
E
Y
S
D
Y
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101480
305
33696
S80
L
R
F
I
S
L
T
S
L
E
Y
S
D
Y
S
Dog
Lupus familis
XP_534645
305
33854
S80
L
R
F
I
S
L
T
S
L
E
Y
S
D
Y
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99LC8
305
33798
S80
L
R
F
I
S
L
T
S
L
E
Y
S
D
Y
S
Rat
Rattus norvegicus
Q64270
305
33660
S80
L
R
F
I
S
L
T
S
L
E
Y
S
D
Y
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507558
316
34903
S91
L
R
F
I
S
L
T
S
L
E
Y
S
E
Y
S
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084600
302
33557
S80
L
R
F
I
T
L
T
S
E
L
E
H
S
N
Y
Zebra Danio
Brachydanio rerio
XP_002662251
302
33553
S80
L
R
F
I
S
L
T
S
L
E
H
P
D
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651752
306
34376
S87
F
C
R
F
I
T
L
S
L
D
D
K
H
M
E
Honey Bee
Apis mellifera
XP_392643
301
33602
A80
F
L
R
F
I
T
L
A
T
L
D
T
P
S
F
Nematode Worm
Caenorhab. elegans
P34604
305
34099
A80
F
T
R
F
T
S
L
A
P
A
A
L
L
D
Q
Sea Urchin
Strong. purpuratus
XP_783380
304
33798
A80
F
L
R
F
I
T
L
A
A
L
D
H
K
N
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P14741
305
34007
L81
M
R
F
V
L
R
N
L
H
L
Y
G
D
W
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.3
96.3
N.A.
94
92.7
N.A.
88.2
N.A.
78
76.3
N.A.
49.6
53.4
43.2
59.3
Protein Similarity:
100
N.A.
99.3
97.3
N.A.
96.7
95
N.A.
92.7
N.A.
88.5
87.2
N.A.
67.6
75.7
63.9
75.7
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
93.3
93.3
N.A.
86.6
N.A.
40
73.3
N.A.
13.3
0
0
0
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
93.3
93.3
N.A.
93.3
N.A.
46.6
80
N.A.
20
13.3
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
24
8
8
8
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
8
24
0
54
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
8
54
8
0
8
0
16
% E
% Phe:
31
0
70
31
0
0
0
0
0
0
0
0
0
0
16
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
16
8
0
0
% H
% Ile:
0
0
0
62
24
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% K
% Leu:
62
16
0
0
8
62
31
8
62
31
0
8
8
8
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
16
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
8
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
70
31
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
54
8
0
70
0
0
0
47
8
8
54
% S
% Thr:
0
8
0
0
16
24
54
0
8
0
0
8
0
0
0
% T
% Val:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
54
0
0
47
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _