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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B1
All Species:
20.91
Human Site:
T256
Identified Species:
38.33
UniProt:
Q14232
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14232
NP_001405.1
305
33712
T256
K
F
K
Y
K
A
D
T
L
K
V
A
Q
T
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101480
305
33696
T256
K
F
K
Y
K
A
D
T
L
K
V
A
Q
T
G
Dog
Lupus familis
XP_534645
305
33854
T256
K
F
K
Y
K
A
D
T
L
K
T
V
Q
T
E
Cat
Felis silvestris
Mouse
Mus musculus
Q99LC8
305
33798
T256
K
F
K
Y
K
A
D
T
L
K
S
V
Q
T
G
Rat
Rattus norvegicus
Q64270
305
33660
T256
K
F
K
Y
K
A
D
T
L
K
S
V
Q
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507558
316
34903
T267
K
F
K
Y
K
A
D
T
L
K
S
K
K
T
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084600
302
33557
K253
V
P
D
K
F
K
Y
K
A
D
T
Q
Q
Q
N
Zebra Danio
Brachydanio rerio
XP_002662251
302
33553
K253
V
P
D
R
F
K
Y
K
A
D
V
L
K
T
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651752
306
34376
Y257
Q
R
D
L
P
N
E
Y
K
Y
S
R
K
H
L
Honey Bee
Apis mellifera
XP_392643
301
33602
K252
V
D
L
P
N
E
F
K
Y
T
A
S
T
L
K
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Y256
D
I
P
Q
E
F
K
Y
R
T
S
V
I
E
R
Sea Urchin
Strong. purpuratus
XP_783380
304
33798
P255
V
P
D
E
Y
K
Y
P
A
S
K
M
K
N
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P14741
305
34007
D255
P
M
A
G
P
P
L
D
F
T
R
R
T
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.3
96.3
N.A.
94
92.7
N.A.
88.2
N.A.
78
76.3
N.A.
49.6
53.4
43.2
59.3
Protein Similarity:
100
N.A.
99.3
97.3
N.A.
96.7
95
N.A.
92.7
N.A.
88.5
87.2
N.A.
67.6
75.7
63.9
75.7
P-Site Identity:
100
N.A.
100
80
N.A.
86.6
80
N.A.
80
N.A.
6.6
13.3
N.A.
0
0
0
0
P-Site Similarity:
100
N.A.
100
80
N.A.
86.6
80
N.A.
86.6
N.A.
6.6
20
N.A.
20
6.6
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
47
0
0
24
0
8
16
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
31
0
0
0
47
8
0
16
0
0
0
8
8
% D
% Glu:
0
0
0
8
8
8
8
0
0
0
0
0
0
8
8
% E
% Phe:
0
47
0
0
16
8
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
39
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
47
0
47
8
47
24
8
24
8
47
8
8
31
0
8
% K
% Leu:
0
0
8
8
0
0
8
0
47
0
0
8
0
8
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
8
8
0
0
0
0
0
0
0
8
16
% N
% Pro:
8
24
8
8
16
8
0
8
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
8
0
0
0
0
0
0
0
8
47
8
0
% Q
% Arg:
0
8
0
8
0
0
0
0
8
0
8
16
0
0
8
% R
% Ser:
0
0
0
0
0
0
0
0
0
8
39
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
47
0
24
16
0
16
47
0
% T
% Val:
31
0
0
0
0
0
0
0
0
0
24
31
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
47
8
0
24
16
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _