KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B1
All Species:
43.94
Human Site:
Y227
Identified Species:
80.56
UniProt:
Q14232
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14232
NP_001405.1
305
33712
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101480
305
33696
Y227
K
A
Q
N
K
P
F
Y
A
V
A
E
S
F
K
Dog
Lupus familis
XP_534645
305
33854
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Cat
Felis silvestris
Mouse
Mus musculus
Q99LC8
305
33798
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Rat
Rattus norvegicus
Q64270
305
33660
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507558
316
34903
Y238
K
A
Q
N
K
L
F
Y
V
V
A
E
S
F
K
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001084600
302
33557
Y227
K
A
Q
N
K
P
F
Y
V
V
A
E
S
F
K
Zebra Danio
Brachydanio rerio
XP_002662251
302
33553
Y227
K
A
H
N
K
P
F
Y
V
V
A
E
S
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651752
306
34376
R227
Y
T
M
G
L
C
A
R
E
M
K
K
P
F
Y
Honey Bee
Apis mellifera
XP_392643
301
33602
Y228
K
E
V
K
K
P
F
Y
V
L
T
E
S
F
K
Nematode Worm
Caenorhab. elegans
P34604
305
34099
Y231
K
S
R
H
V
P
V
Y
V
C
A
E
T
I
K
Sea Urchin
Strong. purpuratus
XP_783380
304
33798
Y228
K
V
V
N
K
P
V
Y
V
V
A
E
S
F
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P14741
305
34007
Y228
H
N
A
R
K
P
F
Y
V
V
T
E
S
H
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.3
96.3
N.A.
94
92.7
N.A.
88.2
N.A.
78
76.3
N.A.
49.6
53.4
43.2
59.3
Protein Similarity:
100
N.A.
99.3
97.3
N.A.
96.7
95
N.A.
92.7
N.A.
88.5
87.2
N.A.
67.6
75.7
63.9
75.7
P-Site Identity:
100
N.A.
93.3
100
N.A.
100
100
N.A.
93.3
N.A.
100
93.3
N.A.
6.6
66.6
46.6
80
P-Site Similarity:
100
N.A.
93.3
100
N.A.
100
100
N.A.
93.3
N.A.
100
93.3
N.A.
20
73.3
73.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
42.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
62
8
0
0
0
8
0
8
0
77
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
8
0
0
93
0
0
0
% E
% Phe:
0
0
0
0
0
0
77
0
0
0
0
0
0
85
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
8
0
8
8
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
85
0
0
8
85
0
0
0
0
0
8
8
0
0
93
% K
% Leu:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
8
0
70
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
85
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
54
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
8
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
0
0
0
0
85
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
16
0
8
0
0
% T
% Val:
0
8
16
0
8
0
16
0
85
77
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
93
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _