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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B1 All Species: 21.52
Human Site: Y252 Identified Species: 39.44
UniProt: Q14232 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14232 NP_001405.1 305 33712 Y252 D V P D K F K Y K A D T L K V
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001101480 305 33696 Y252 D V P D K F K Y K A D T L K V
Dog Lupus familis XP_534645 305 33854 Y252 D V P D K F K Y K A D T L K T
Cat Felis silvestris
Mouse Mus musculus Q99LC8 305 33798 Y252 D V P D K F K Y K A D T L K S
Rat Rattus norvegicus Q64270 305 33660 Y252 D V P D K F K Y K A D T L K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507558 316 34903 Y263 D V P D K F K Y K A D T L K S
Chicken Gallus gallus
Frog Xenopus laevis NP_001084600 302 33557 K249 N Q Q D V P D K F K Y K A D T
Zebra Danio Brachydanio rerio XP_002662251 302 33553 R249 N Q Q D V P D R F K Y K A D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_651752 306 34376 L253 Y P L N Q R D L P N E Y K Y S
Honey Bee Apis mellifera XP_392643 301 33602 P248 P L N Q V D L P N E F K Y T A
Nematode Worm Caenorhab. elegans P34604 305 34099 Q252 L N Q A D I P Q E F K Y R T S
Sea Urchin Strong. purpuratus XP_783380 304 33798 E251 N Q Q D V P D E Y K Y P A S K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P14741 305 34007 G251 S D D L P M A G P P L D F T R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 99.3 96.3 N.A. 94 92.7 N.A. 88.2 N.A. 78 76.3 N.A. 49.6 53.4 43.2 59.3
Protein Similarity: 100 N.A. 99.3 97.3 N.A. 96.7 95 N.A. 92.7 N.A. 88.5 87.2 N.A. 67.6 75.7 63.9 75.7
P-Site Identity: 100 N.A. 100 93.3 N.A. 93.3 93.3 N.A. 93.3 N.A. 6.6 13.3 N.A. 0 0 0 6.6
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 93.3 N.A. 93.3 N.A. 13.3 20 N.A. 20 6.6 6.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 42.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 59.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 8 0 0 47 0 0 24 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 47 8 8 70 8 8 31 0 0 0 47 8 0 16 0 % D
% Glu: 0 0 0 0 0 0 0 8 8 8 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 47 0 0 16 8 8 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 47 0 47 8 47 24 8 24 8 47 8 % K
% Leu: 8 8 8 8 0 0 8 8 0 0 8 0 47 0 0 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 24 8 8 8 0 0 0 0 8 8 0 0 0 0 0 % N
% Pro: 8 8 47 0 8 24 8 8 16 8 0 8 0 0 0 % P
% Gln: 0 24 31 8 8 0 0 8 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 8 0 8 0 0 0 0 8 0 8 % R
% Ser: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 39 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 47 0 24 16 % T
% Val: 0 47 0 0 31 0 0 0 0 0 0 0 0 0 24 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 47 8 0 24 16 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _