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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A2
All Species:
31.52
Human Site:
Y171
Identified Species:
46.22
UniProt:
Q14240
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14240
NP_001958.2
407
46402
Y171
F
D
M
L
N
R
R
Y
L
S
P
K
W
I
K
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
Y170
F
D
M
L
N
R
R
Y
L
S
P
K
Y
I
K
Rhesus Macaque
Macaca mulatta
XP_001102692
380
43227
F164
V
G
T
P
G
R
V
F
D
M
L
N
R
R
Y
Dog
Lupus familis
XP_860391
360
41029
M145
G
T
N
V
R
N
E
M
Q
K
L
Q
A
E
A
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
Y171
F
D
M
L
N
R
R
Y
L
S
P
K
W
I
K
Rat
Rattus norvegicus
NP_001008336
407
46384
Y171
F
D
M
L
N
R
R
Y
L
S
P
K
W
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q8JFP1
407
46353
Y171
F
D
M
L
N
R
R
Y
L
S
P
K
W
I
K
Frog
Xenopus laevis
NP_001085314
406
46000
Y170
F
D
M
L
N
R
R
Y
L
S
P
K
Y
I
K
Zebra Danio
Brachydanio rerio
Q7ZVA6
406
46449
S170
F
D
M
I
R
R
R
S
L
R
T
R
A
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
V167
Y
D
M
I
N
R
K
V
L
R
T
Q
Y
I
K
Honey Bee
Apis mellifera
XP_623285
423
48137
A187
Y
D
M
I
S
R
R
A
L
R
A
S
S
I
K
Nematode Worm
Caenorhab. elegans
P27639
402
45389
A166
G
D
M
I
N
R
N
A
L
D
T
S
R
I
K
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
V190
F
D
M
L
K
R
K
V
L
S
P
F
K
I
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
S174
F
D
M
L
R
R
Q
S
L
R
P
D
N
I
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
S176
F
D
M
L
K
R
Q
S
L
R
A
D
N
I
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
F161
H
D
M
I
Q
R
R
F
L
K
T
D
S
M
K
Conservation
Percent
Protein Identity:
100
89.4
93.1
88.4
N.A.
100
100
N.A.
N.A.
97.7
90.4
67
N.A.
71.7
75.1
69.2
75.1
Protein Similarity:
100
96
93.3
88.4
N.A.
100
100
N.A.
N.A.
99.5
95.8
80.3
N.A.
86.9
87.2
83
84
P-Site Identity:
100
93.3
6.6
0
N.A.
100
100
N.A.
N.A.
100
93.3
53.3
N.A.
46.6
46.6
46.6
60
P-Site Similarity:
100
100
13.3
13.3
N.A.
100
100
N.A.
N.A.
100
100
66.6
N.A.
80
66.6
53.3
66.6
Percent
Protein Identity:
N.A.
68.7
N.A.
68.6
N.A.
74.9
Protein Similarity:
N.A.
83.1
N.A.
82
N.A.
86.9
P-Site Identity:
N.A.
60
N.A.
53.3
N.A.
40
P-Site Similarity:
N.A.
66.6
N.A.
60
N.A.
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
13
0
0
13
0
13
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
88
0
0
0
0
0
0
7
7
0
19
0
0
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% E
% Phe:
63
0
0
0
0
0
0
13
0
0
0
7
0
0
0
% F
% Gly:
13
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% G
% His:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
32
0
0
0
0
0
0
0
0
0
82
0
% I
% Lys:
0
0
0
0
13
0
13
0
0
13
0
38
7
0
82
% K
% Leu:
0
0
0
57
0
0
0
0
88
0
13
0
0
0
0
% L
% Met:
0
0
88
0
0
0
0
7
0
7
0
0
0
7
0
% M
% Asn:
0
0
7
0
50
7
7
0
0
0
0
7
13
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
50
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
13
0
7
0
0
13
0
0
0
% Q
% Arg:
0
0
0
0
19
94
57
0
0
32
0
7
13
7
0
% R
% Ser:
0
0
0
0
7
0
0
19
0
44
0
13
13
0
0
% S
% Thr:
0
7
7
0
0
0
0
0
0
0
25
0
0
0
0
% T
% Val:
7
0
0
7
0
0
7
13
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
0
% W
% Tyr:
13
0
0
0
0
0
0
38
0
0
0
0
19
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _