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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF4A2
All Species:
27.27
Human Site:
Y71
Identified Species:
40
UniProt:
Q14240
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14240
NP_001958.2
407
46402
Y71
I
I
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Chimpanzee
Pan troglodytes
A5A6N4
406
46165
Y70
I
L
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Rhesus Macaque
Macaca mulatta
XP_001102692
380
43227
Y71
I
I
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Dog
Lupus familis
XP_860391
360
41029
G52
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Cat
Felis silvestris
Mouse
Mus musculus
P10630
407
46384
Y71
I
I
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Rat
Rattus norvegicus
NP_001008336
407
46384
Y71
I
I
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q8JFP1
407
46353
Y71
I
I
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Frog
Xenopus laevis
NP_001085314
406
46000
Y70
I
M
P
C
I
K
G
Y
D
V
I
A
Q
A
Q
Zebra Danio
Brachydanio rerio
Q7ZVA6
406
46449
R71
I
K
Q
I
I
K
G
R
D
V
I
A
Q
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q02748
403
45860
R68
I
I
P
C
V
R
G
R
D
V
I
A
Q
A
Q
Honey Bee
Apis mellifera
XP_623285
423
48137
H88
I
L
P
C
I
R
G
H
D
V
I
A
Q
A
Q
Nematode Worm
Caenorhab. elegans
P27639
402
45389
K67
I
V
P
C
T
T
G
K
D
V
I
A
Q
A
Q
Sea Urchin
Strong. purpuratus
NP_001091916
426
48260
K91
I
L
P
C
C
E
G
K
D
V
I
A
Q
A
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q41741
410
46518
L75
I
V
P
F
C
K
G
L
D
V
I
Q
Q
A
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P41376
412
46686
L77
I
V
P
F
C
K
G
L
D
V
I
Q
Q
A
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7RV88
397
44826
A66
I
K
G
H
D
V
I
A
Q
A
Q
S
G
T
G
Conservation
Percent
Protein Identity:
100
89.4
93.1
88.4
N.A.
100
100
N.A.
N.A.
97.7
90.4
67
N.A.
71.7
75.1
69.2
75.1
Protein Similarity:
100
96
93.3
88.4
N.A.
100
100
N.A.
N.A.
99.5
95.8
80.3
N.A.
86.9
87.2
83
84
P-Site Identity:
100
93.3
100
6.6
N.A.
100
100
N.A.
N.A.
100
93.3
66.6
N.A.
80
80
73.3
73.3
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
100
100
73.3
N.A.
93.3
100
80
86.6
Percent
Protein Identity:
N.A.
68.7
N.A.
68.6
N.A.
74.9
Protein Similarity:
N.A.
83.1
N.A.
82
N.A.
86.9
P-Site Identity:
N.A.
66.6
N.A.
66.6
N.A.
6.6
P-Site Similarity:
N.A.
73.3
N.A.
73.3
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
7
0
7
0
75
0
88
0
% A
% Cys:
0
0
0
69
19
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
88
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% E
% Phe:
0
0
0
13
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
0
88
7
0
0
0
0
7
0
7
% G
% His:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
94
38
0
13
57
0
7
0
0
0
88
0
0
0
7
% I
% Lys:
0
13
0
0
0
63
0
13
0
0
7
0
0
0
0
% K
% Leu:
7
19
0
0
0
0
0
13
0
0
0
0
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
82
0
0
0
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
0
7
0
0
0
0
0
7
0
7
13
88
0
88
% Q
% Arg:
0
7
0
0
0
13
0
13
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
7
7
7
0
% S
% Thr:
0
0
0
0
7
7
0
0
0
0
0
0
0
7
0
% T
% Val:
0
19
0
0
7
7
0
0
0
88
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
7
44
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _