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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FRG1 All Species: 19.09
Human Site: S21 Identified Species: 35
UniProt: Q14331 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.42
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14331 NP_004468.1 258 29172 S21 L K G T K T K S K K K K S K D
Chimpanzee Pan troglodytes XP_001136401 250 28131 S21 L K G T K T K S K K K K S K D
Rhesus Macaque Macaca mulatta XP_001090694 258 29090 S21 L K G T K A K S K K K K S K D
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P97376 258 29109 S21 L K G T K A K S K K K K S K D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516374 198 22206
Chicken Gallus gallus XP_420681 256 28915 S21 L K G A K E K S K K K H K N K
Frog Xenopus laevis NP_001086250 210 23113
Zebra Danio Brachydanio rerio NP_001017793 255 28761 K21 L K G S N D K K K K K N K D K
Tiger Blowfish Takifugu rubipres O73747 255 28711 K21 L K G Q K Q G K K H K H K D R
Fruit Fly Dros. melanogaster Q9VWA8 262 29511 R25 K L K K S K K R K K E K D E A
Honey Bee Apis mellifera XP_625206 258 29196 T21 L K G E K K R T K K R K L K K
Nematode Worm Caenorhab. elegans O18282 274 30250 K32 K V G K E K K K K N K D D K E
Sea Urchin Strong. purpuratus XP_001204166 254 28213 K29 S S S K K H K K K R K R E H E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 99.2 N.A. N.A. 97.2 N.A. N.A. 64.3 85.6 66.6 76.7 71.7 48.4 53.8 43.4 53.4
Protein Similarity: 100 96.5 99.2 N.A. N.A. 99.2 N.A. N.A. 70.5 92.2 73.6 89.1 85.2 66 71.3 60.9 70.1
P-Site Identity: 100 100 93.3 N.A. N.A. 93.3 N.A. N.A. 0 60 0 46.6 40 26.6 53.3 33.3 26.6
P-Site Similarity: 100 100 93.3 N.A. N.A. 93.3 N.A. N.A. 0 60 0 53.3 40 40 73.3 46.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 16 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 0 8 16 16 31 % D
% Glu: 0 0 0 8 8 8 0 0 0 0 8 0 8 8 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 70 0 0 0 8 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 8 0 16 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 16 62 8 24 62 24 70 31 85 62 70 47 24 47 24 % K
% Leu: 62 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 0 0 0 0 8 0 8 0 8 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 8 8 0 8 8 8 0 0 8 % R
% Ser: 8 8 8 8 8 0 0 39 0 0 0 0 31 0 0 % S
% Thr: 0 0 0 31 0 16 0 8 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _