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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GRM2 All Species: 26.67
Human Site: S501 Identified Species: 48.89
UniProt: Q14416 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14416 NP_000830.2 872 95568 S501 P L P A S R C S E P C L Q N E
Chimpanzee Pan troglodytes A3QNZ8 839 95029 S467 N P F Q S V A S Y Y P L Q R Q
Rhesus Macaque Macaca mulatta A3QP01 839 95041 S467 N P F Q S V A S Y Y P L Q R Q
Dog Lupus familis XP_541867 872 95696 S501 S L P A S R C S E P C L Q N E
Cat Felis silvestris
Mouse Mus musculus Q14BI2 872 95869 S501 T L P A S R C S E P C L Q N E
Rat Rattus norvegicus P31421 872 95755 S501 P L P A S R C S E P C L Q N E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518731 870 95758 S501 S P P T S Q C S D P C R K N E
Chicken Gallus gallus XP_416842 879 98936 S510 S V P V S Q C S D P C A P N E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q5U9X3 867 97118 S497 V V S R C S N S C Q P G Q Y K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91685 976 108467 L562 Q P T S A C S L P C E V G M I
Honey Bee Apis mellifera NP_001011624 933 103448 L541 I P I S A C S L P C E P G M I
Nematode Worm Caenorhab. elegans Q09630 999 113258 W601 I Y E K N L W W D P D H T P V
Sea Urchin Strong. purpuratus XP_784936 1474 165598 S1084 N V P Y S Q C S M P C G P G Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.6 27.6 98.1 N.A. 97.4 97.8 N.A. 88.3 67.9 N.A. 25.5 N.A. 45.7 47 39.9 32.2
Protein Similarity: 100 46.3 46.3 98.9 N.A. 98.5 98.7 N.A. 92.7 82.2 N.A. 43.8 N.A. 61.7 63.3 55.6 43.4
P-Site Identity: 100 26.6 26.6 93.3 N.A. 93.3 100 N.A. 53.3 53.3 N.A. 13.3 N.A. 0 0 6.6 40
P-Site Similarity: 100 33.3 33.3 93.3 N.A. 93.3 100 N.A. 73.3 73.3 N.A. 26.6 N.A. 20 13.3 20 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 31 16 0 16 0 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 8 16 54 0 8 16 54 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 24 0 8 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 31 0 16 0 0 0 47 % E
% Phe: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 16 16 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 16 0 8 0 0 0 0 0 0 0 0 0 0 0 16 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 8 % K
% Leu: 0 31 0 0 0 8 0 16 0 0 0 47 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 16 0 % M
% Asn: 24 0 0 0 8 0 8 0 0 0 0 0 0 47 0 % N
% Pro: 16 39 54 0 0 0 0 0 16 62 24 8 16 8 0 % P
% Gln: 8 0 0 16 0 24 0 0 0 8 0 0 54 0 24 % Q
% Arg: 0 0 0 8 0 31 0 0 0 0 0 8 0 16 0 % R
% Ser: 24 0 8 16 70 8 16 77 0 0 0 0 0 0 0 % S
% Thr: 8 0 8 8 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 8 24 0 8 0 16 0 0 0 0 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 8 0 0 0 0 16 16 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _