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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3A
All Species:
14.24
Human Site:
S523
Identified Species:
26.11
UniProt:
Q14432
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14432
NP_000912.3
1141
124979
S523
L
A
K
I
S
P
L
S
S
P
C
S
S
P
L
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
S523
L
A
K
I
S
P
L
S
S
P
C
S
S
P
L
Rhesus Macaque
Macaca mulatta
XP_001096963
1141
124707
S523
L
A
K
I
S
P
L
S
S
P
C
S
S
P
L
Dog
Lupus familis
XP_854529
779
87136
H242
S
L
C
N
S
C
G
H
Q
I
L
K
Y
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0X4
1141
124494
S520
P
G
G
L
A
K
I
S
P
V
P
S
P
S
S
Rat
Rattus norvegicus
Q62865
1141
124282
S520
P
G
G
L
D
K
I
S
P
V
P
S
P
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
XP_416416
825
91797
S288
G
D
G
T
L
D
R
S
D
G
T
T
H
T
L
Frog
Xenopus laevis
NP_001088828
985
108702
F448
L
A
S
T
S
Q
D
F
Q
P
Q
V
R
S
P
Zebra Danio
Brachydanio rerio
XP_695432
1117
123518
S457
K
S
R
R
G
C
S
S
S
T
I
S
P
L
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W4T4
1209
129395
Q458
G
G
T
A
T
T
T
Q
N
S
S
S
V
S
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
A88
T
G
S
S
L
S
E
A
K
G
L
I
A
D
M
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
P863
S
P
S
P
N
L
M
P
P
D
G
K
G
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.5
38.2
N.A.
84
84.6
N.A.
20.9
59.6
43.9
57.8
N.A.
20.8
N.A.
26.7
29.9
Protein Similarity:
100
99.7
98.4
49.6
N.A.
89.3
90
N.A.
25.1
63.9
58.3
71.2
N.A.
36.3
N.A.
37.9
43.2
P-Site Identity:
100
100
100
6.6
N.A.
13.3
13.3
N.A.
0
13.3
26.6
20
N.A.
6.6
N.A.
0
0
P-Site Similarity:
100
100
100
6.6
N.A.
33.3
26.6
N.A.
0
20
26.6
33.3
N.A.
26.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
31
0
8
8
0
0
8
0
0
0
0
8
0
8
% A
% Cys:
0
0
8
0
0
16
0
0
0
0
24
0
0
0
0
% C
% Asp:
0
8
0
0
8
8
8
0
8
8
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
16
31
24
0
8
0
8
0
0
16
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
0
24
0
0
16
0
0
8
8
8
0
0
0
% I
% Lys:
8
0
24
0
0
16
0
0
8
0
0
16
0
0
0
% K
% Leu:
31
8
0
16
16
8
24
0
0
0
16
0
0
16
31
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
8
8
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
16
8
0
8
0
24
0
8
24
31
16
0
24
24
8
% P
% Gln:
0
0
0
0
0
8
0
8
16
0
8
0
0
0
0
% Q
% Arg:
0
0
8
8
0
0
8
0
0
0
0
0
8
0
8
% R
% Ser:
16
8
24
8
39
8
8
54
31
8
8
54
24
31
24
% S
% Thr:
8
0
8
16
8
8
8
0
0
8
8
8
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
16
0
8
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _