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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES1
All Species:
22.73
Human Site:
Y110
Identified Species:
50
UniProt:
Q14469
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14469
NP_005515.1
280
29541
Y110
D
P
S
V
L
G
K
Y
R
A
G
F
S
E
C
Chimpanzee
Pan troglodytes
XP_001162588
239
25232
P115
Q
I
N
A
M
T
Y
P
G
Q
P
H
P
A
L
Rhesus Macaque
Macaca mulatta
XP_001090404
221
23576
G108
N
A
D
P
A
V
L
G
K
Y
R
A
G
F
H
Dog
Lupus familis
XP_546724
225
24255
Y110
D
P
A
V
L
G
K
Y
R
A
G
F
N
E
C
Cat
Felis silvestris
Mouse
Mus musculus
P35428
282
29730
Y110
D
P
S
V
L
G
K
Y
R
A
G
F
S
E
C
Rat
Rattus norvegicus
Q04666
281
29603
Y110
D
P
S
V
L
G
K
Y
R
A
G
F
S
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511924
287
29320
V113
F
L
S
T
C
E
G
V
N
T
E
V
R
T
R
Chicken
Gallus gallus
O57337
290
31053
Y111
D
P
S
V
L
G
K
Y
R
A
G
F
N
E
C
Frog
Xenopus laevis
Q6IRB2
267
28706
Y110
D
P
S
V
L
G
K
Y
R
A
G
F
S
E
C
Zebra Danio
Brachydanio rerio
Q8AXV5
310
33373
L119
L
A
V
D
Y
R
T
L
G
F
R
E
C
V
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
F116
D
P
S
V
V
Q
K
F
K
T
G
F
V
E
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
49.2
50
N.A.
97.5
98.5
N.A.
73.5
54.1
73.5
29.3
N.A.
31.7
N.A.
N.A.
N.A.
Protein Similarity:
100
85.3
61
61.4
N.A.
97.8
98.5
N.A.
78
61.3
80.3
45.1
N.A.
41.8
N.A.
N.A.
N.A.
P-Site Identity:
100
0
0
86.6
N.A.
100
100
N.A.
6.6
93.3
100
0
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
13.3
100
N.A.
100
100
N.A.
6.6
100
100
0
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
10
10
10
0
0
0
0
55
0
10
0
10
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
0
0
0
10
0
64
% C
% Asp:
64
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
10
10
0
64
0
% E
% Phe:
10
0
0
0
0
0
0
10
0
10
0
64
0
10
0
% F
% Gly:
0
0
0
0
0
55
10
10
19
0
64
0
10
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% H
% Ile:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
64
0
19
0
0
0
0
0
0
% K
% Leu:
10
10
0
0
55
0
10
10
0
0
0
0
0
0
10
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
10
0
0
0
0
0
10
0
0
0
19
0
0
% N
% Pro:
0
64
0
10
0
0
0
10
0
0
10
0
10
0
0
% P
% Gln:
10
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
55
0
19
0
10
0
10
% R
% Ser:
0
0
64
0
0
0
0
0
0
0
0
0
37
0
0
% S
% Thr:
0
0
0
10
0
10
10
0
0
19
0
0
0
10
0
% T
% Val:
0
0
10
64
10
10
0
10
0
0
0
10
10
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
10
55
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _