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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FAT1 All Species: 4.55
Human Site: S4501 Identified Species: 10
UniProt: Q14517 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14517 NP_005236.2 4590 506278 S4501 N F Y P L D M S E P Q T K G T
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001084587 4609 507875 P4520 Y L P P H P F P N E T D L V G
Dog Lupus familis XP_532835 4692 518122 S4529 N F Y P V D M S E P Q K T G S
Cat Felis silvestris
Mouse Mus musculus Q8BNA6 4555 501992 P4466 Y L P P H P L P G E T D L G G
Rat Rattus norvegicus Q8R508 4555 502069 P4466 Y L P P H P L P G E T D L G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508966 4273 469286 D4185 P R P P S P R D R P P V P C Q
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998132 4610 506620 Q4518 Y S S D P E P Q T N P T S T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VW71 4705 524557 T4616 N E D Y K S N T G K V Y L R H
Honey Bee Apis mellifera XP_394631 3607 400577 E3519 N G R L S T L E S D E E E D D
Nematode Worm Caenorhab. elegans Q19319 4292 477180 G4204 K Y S R A A A G T V I V G D T
Sea Urchin Strong. purpuratus XP_785422 3852 424350 P3764 G G S T S T V P P D Y D G I G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 51.7 88.9 N.A. 51.6 51.7 N.A. 43.2 N.A. N.A. 64.4 N.A. 36.3 32.3 27.9 22.4
Protein Similarity: 100 N.A. 69.3 93.4 N.A. 69.3 69.2 N.A. 61.1 N.A. N.A. 80 N.A. 55.7 47.6 47.9 39.7
P-Site Identity: 100 N.A. 6.6 73.3 N.A. 13.3 13.3 N.A. 13.3 N.A. N.A. 6.6 N.A. 6.6 6.6 6.6 0
P-Site Similarity: 100 N.A. 6.6 86.6 N.A. 20 20 N.A. 13.3 N.A. N.A. 13.3 N.A. 13.3 26.6 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 10 10 10 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 10 10 0 19 0 10 0 19 0 37 0 19 10 % D
% Glu: 0 10 0 0 0 10 0 10 19 28 10 10 10 0 0 % E
% Phe: 0 19 0 0 0 0 10 0 0 0 0 0 0 0 0 % F
% Gly: 10 19 0 0 0 0 0 10 28 0 0 0 19 37 37 % G
% His: 0 0 0 0 28 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 10 % I
% Lys: 10 0 0 0 10 0 0 0 0 10 0 10 10 0 0 % K
% Leu: 0 28 0 10 10 0 28 0 0 0 0 0 37 0 0 % L
% Met: 0 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % M
% Asn: 37 0 0 0 0 0 10 0 10 10 0 0 0 0 0 % N
% Pro: 10 0 37 55 10 37 10 37 10 28 19 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 19 0 0 0 10 % Q
% Arg: 0 10 10 10 0 0 10 0 10 0 0 0 0 10 0 % R
% Ser: 0 10 28 0 28 10 0 19 10 0 0 0 10 0 10 % S
% Thr: 0 0 0 10 0 19 0 10 19 0 28 19 10 10 19 % T
% Val: 0 0 0 0 10 0 10 0 0 10 10 19 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 37 10 19 10 0 0 0 0 0 0 10 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _