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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
22.12
Human Site:
S257
Identified Species:
37.44
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
S257
W
M
V
S
R
E
N
S
K
E
L
P
P
F
W
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
S257
W
M
V
S
R
E
N
S
K
E
L
P
P
F
W
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
S356
W
M
V
S
R
E
N
S
K
D
L
P
P
F
W
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
S257
W
M
I
A
R
E
N
S
K
E
L
P
P
F
W
Rat
Rattus norvegicus
NP_001099948
974
110023
V236
E
M
E
P
A
E
A
V
E
T
P
L
L
P
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
K226
G
D
N
I
S
C
E
K
L
D
E
V
C
K
E
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
T253
E
P
A
E
V
V
G
T
K
L
L
S
H
Q
K
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
S243
W
M
S
S
R
E
N
S
N
D
L
P
P
F
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
S277
S
P
A
A
P
R
R
S
R
I
K
S
E
D
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
A303
G
K
T
L
T
V
I
A
L
V
L
H
D
F
A
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
E141
S
E
A
M
V
V
K
E
K
N
K
K
S
G
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
P223
K
L
V
A
A
E
P
P
R
E
V
I
K
S
E
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
T132
K
K
K
K
K
T
S
T
K
K
K
S
P
K
V
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
S313
I
V
R
F
N
D
A
S
G
R
E
L
G
R
L
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
93.3
N.A.
86.6
13.3
N.A.
0
N.A.
13.3
80
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
N.A.
100
N.A.
100
20
N.A.
6.6
N.A.
20
86.6
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
6.6
N.A.
N.A.
20
13.3
6.6
P-Site Similarity:
6.6
N.A.
N.A.
46.6
40
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
22
22
15
0
15
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
8
0
0
0
8
0
0
0
22
0
0
8
8
0
% D
% Glu:
15
8
8
8
0
50
8
8
8
29
15
0
8
0
15
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
0
43
0
% F
% Gly:
15
0
0
0
0
0
8
0
8
0
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
8
% H
% Ile:
8
0
8
8
0
0
8
0
0
8
0
8
0
0
0
% I
% Lys:
15
15
8
8
8
0
8
8
50
8
22
8
8
15
8
% K
% Leu:
0
8
0
8
0
0
0
0
15
8
50
15
8
0
15
% L
% Met:
0
43
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
8
0
36
0
8
8
0
0
0
0
0
% N
% Pro:
0
15
0
8
8
0
8
8
0
0
8
36
43
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
0
8
0
36
8
8
0
15
8
0
0
0
8
0
% R
% Ser:
15
0
8
29
8
0
8
50
0
0
0
22
8
8
0
% S
% Thr:
0
0
8
0
8
8
0
15
0
8
0
0
0
0
0
% T
% Val:
0
8
29
0
15
22
0
8
0
8
8
8
0
0
8
% V
% Trp:
36
0
0
0
0
0
0
0
0
0
0
0
0
0
36
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _