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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX8 All Species: 15.45
Human Site: S226 Identified Species: 28.33
UniProt: Q14562 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14562 NP_004932.1 1220 139315 S226 K S R Y R S R S R S Q S P P K
Chimpanzee Pan troglodytes Q7YR39 1044 119631 S154 G K K K T G G S K Q Q T E K P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537627 1216 138553 S222 K S R Y R S R S R S Q S P P K
Cat Felis silvestris
Mouse Mus musculus A2A4P0 1244 142553 S250 K S R Y R S R S R S Q S P F K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418105 1076 123154 D186 R S R S R T R D R N R G K S R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002663993 1210 138002 S220 K R R S R W H S R S R S R S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610928 1242 141917 R219 S R S R D N R R R S R S R E D
Honey Bee Apis mellifera XP_623289 1192 136394 S205 R S R D R K R S R S R D R K F
Nematode Worm Caenorhab. elegans Q09530 1200 135741 R202 D R D R D R D R G R G D R R G
Sea Urchin Strong. purpuratus O17438 455 51461
Poplar Tree Populus trichocarpa XP_002318357 1207 137837 R217 D G G G E R E R R N V R H G Y
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38953 1168 134139 R195 E D R R R D R R A K D E Y V E
Baker's Yeast Sacchar. cerevisiae P24384 1145 129992 C205 F G T R M K N C D G L V H I S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 40 N.A. 98.5 N.A. 96.8 N.A. N.A. N.A. 84 N.A. 91.1 N.A. 69.4 71.8 61.3 21.9
Protein Similarity: 100 59 N.A. 99.1 N.A. 97.3 N.A. N.A. N.A. 86.8 N.A. 94.5 N.A. 82 83.9 75.4 28.8
P-Site Identity: 100 13.3 N.A. 100 N.A. 93.3 N.A. N.A. N.A. 33.3 N.A. 46.6 N.A. 26.6 46.6 0 0
P-Site Similarity: 100 33.3 N.A. 100 N.A. 93.3 N.A. N.A. N.A. 66.6 N.A. 53.3 N.A. 40 60 0 0
Percent
Protein Identity: 59.1 N.A. N.A. 59.3 44.2 N.A.
Protein Similarity: 75 N.A. N.A. 75.4 62.8 N.A.
P-Site Identity: 6.6 N.A. N.A. 20 0 N.A.
P-Site Similarity: 13.3 N.A. N.A. 33.3 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 16 8 8 8 16 8 8 8 8 0 8 16 0 0 8 % D
% Glu: 8 0 0 0 8 0 8 0 0 0 0 8 8 8 8 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % F
% Gly: 8 16 8 8 0 8 8 0 8 8 8 8 0 8 8 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 16 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 31 8 8 8 0 16 0 0 8 8 0 0 8 16 24 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % L
% Met: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 8 0 0 16 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 24 16 16 % P
% Gln: 0 0 0 0 0 0 0 0 0 8 31 0 0 0 0 % Q
% Arg: 16 24 54 31 54 16 54 31 62 8 31 8 31 8 8 % R
% Ser: 8 39 8 16 0 24 0 47 0 47 0 39 0 16 8 % S
% Thr: 0 0 8 0 8 8 0 0 0 0 0 8 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 8 8 0 8 0 % V
% Trp: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 24 0 0 0 0 0 0 0 0 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _