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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM6 All Species: 53.94
Human Site: S420 Identified Species: 74.17
UniProt: Q14566 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14566 NP_005906.2 821 92889 S420 S P R A V Y T S G K A S S A A
Chimpanzee Pan troglodytes XP_001154613 821 92903 S420 S P R A V Y T S G K A S S A A
Rhesus Macaque Macaca mulatta XP_001096068 821 92830 S420 S P R A V Y T S G K A S S A A
Dog Lupus familis XP_533338 955 107181 S554 S P R A V Y T S G K A S S A A
Cat Felis silvestris
Mouse Mus musculus P97311 821 92849 S420 S P R A V Y T S G K A S S A A
Rat Rattus norvegicus Q62724 507 57351 Q166 I H E A M E Q Q T I S I T K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510510 779 87819 E399 E S H E F V I E A G A L M L A
Chicken Gallus gallus NP_001006527 916 103481 S421 S P R A V Y T S G K A S S A A
Frog Xenopus laevis Q7ZY18 825 93359 S421 S P R A V Y T S G K A S T A A
Zebra Danio Brachydanio rerio XP_002662351 830 93777 S418 C P R A V Y T S G K A S S A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V461 817 92334 S412 S P R A I Y T S G K A S S A A
Honey Bee Apis mellifera XP_396515 813 91942 S413 V P R S I Y T S G K A S S A A
Nematode Worm Caenorhab. elegans P34647 810 91112 S421 S P R A I Y T S G K A S S A A
Sea Urchin Strong. purpuratus XP_783166 823 93674 S414 S P R A V Y T S G K A S S A A
Poplar Tree Populus trichocarpa
Maize Zea mays Q43704 768 85163 I403 A D R G V V C I D E F D K M N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 M375 G D V H I C L M G D P G V A K
Baker's Yeast Sacchar. cerevisiae P53091 1017 112934 S599 A P R S V Y T S G K A S S A A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.7 83.8 N.A. 95.8 58.9 N.A. 84.7 78.5 82.6 80.9 N.A. 63.5 59.8 54.8 71.5
Protein Similarity: 100 100 100 84.7 N.A. 97.6 60.5 N.A. 89.7 84.8 91.1 89.2 N.A. 79 76.3 71.7 84.2
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 13.3 100 93.3 93.3 N.A. 93.3 80 93.3 100
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. 13.3 100 100 93.3 N.A. 100 93.3 100 100
Percent
Protein Identity: N.A. 26.4 N.A. 25.8 38.5 N.A.
Protein Similarity: N.A. 45.6 N.A. 44.7 56.5 N.A.
P-Site Identity: N.A. 13.3 N.A. 13.3 86.6 N.A.
P-Site Similarity: N.A. 26.6 N.A. 20 100 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 71 0 0 0 0 6 0 83 0 0 83 89 % A
% Cys: 6 0 0 0 0 6 6 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 0 0 0 0 0 0 6 6 0 6 0 0 0 % D
% Glu: 6 0 6 6 0 6 0 6 0 6 0 0 0 0 0 % E
% Phe: 0 0 0 0 6 0 0 0 0 0 6 0 0 0 0 % F
% Gly: 6 0 0 6 0 0 0 0 83 6 0 6 0 0 0 % G
% His: 0 6 6 6 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 0 0 24 0 6 6 0 6 0 6 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 77 0 0 6 6 6 % K
% Leu: 0 0 0 0 0 0 6 0 0 0 0 6 0 6 0 % L
% Met: 0 0 0 0 6 0 0 6 0 0 0 0 6 6 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6 % N
% Pro: 0 77 0 0 0 0 0 0 0 0 6 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 6 6 0 0 0 0 0 0 0 % Q
% Arg: 0 0 83 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 59 6 0 12 0 0 0 77 0 0 6 77 71 0 0 % S
% Thr: 0 0 0 0 0 0 77 0 6 0 0 0 12 0 0 % T
% Val: 6 0 6 0 65 12 0 0 0 0 0 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 77 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _