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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM6 All Species: 32.42
Human Site: T259 Identified Species: 44.58
UniProt: Q14566 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q14566 NP_005906.2 821 92889 T259 P D V S K L S T P G A R A E T
Chimpanzee Pan troglodytes XP_001154613 821 92903 T259 P D V S K L S T P G A R A E T
Rhesus Macaque Macaca mulatta XP_001096068 821 92830 T259 P D V S K L S T P G A R A E T
Dog Lupus familis XP_533338 955 107181 I393 P D V S K L S I P G A R A E T
Cat Felis silvestris
Mouse Mus musculus P97311 821 92849 T259 P D V S K L S T P G A R A E T
Rat Rattus norvegicus Q62724 507 57351 K12 E Q T A E S I K N Q M T V K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510510 779 87819 D245 L R A L G V R D L S Y K L V F
Chicken Gallus gallus NP_001006527 916 103481 T260 P D V A Q L S T P G V R A E T
Frog Xenopus laevis Q7ZY18 825 93359 T260 P D I S Q L S T P G V R A E T
Zebra Danio Brachydanio rerio XP_002662351 830 93777 T257 P D I S Q L A T P G V R A E T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V461 817 92334 L251 V V P D V S V L A G V G T R A
Honey Bee Apis mellifera XP_396515 813 91942 L253 P D I S V L S L P G V K A D L
Nematode Worm Caenorhab. elegans P34647 810 91112 T258 P D I A Q L S T P G L R A E T
Sea Urchin Strong. purpuratus XP_783166 823 93674 M253 P D V S T L S M P G A R A E T
Poplar Tree Populus trichocarpa
Maize Zea mays Q43704 768 85163 V248 P G K S K G S V S G V F R T V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P43299 716 80315 S221 P I L Q L R A S K F L K F Q E
Baker's Yeast Sacchar. cerevisiae P53091 1017 112934 L412 P D V T Q L G L P G V K P S S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.7 83.8 N.A. 95.8 58.9 N.A. 84.7 78.5 82.6 80.9 N.A. 63.5 59.8 54.8 71.5
Protein Similarity: 100 100 100 84.7 N.A. 97.6 60.5 N.A. 89.7 84.8 91.1 89.2 N.A. 79 76.3 71.7 84.2
P-Site Identity: 100 100 100 93.3 N.A. 100 0 N.A. 0 80 80 73.3 N.A. 6.6 53.3 73.3 86.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 20 N.A. 13.3 93.3 93.3 93.3 N.A. 6.6 73.3 93.3 86.6
Percent
Protein Identity: N.A. 26.4 N.A. 25.8 38.5 N.A.
Protein Similarity: N.A. 45.6 N.A. 44.7 56.5 N.A.
P-Site Identity: N.A. 33.3 N.A. 6.6 40 N.A.
P-Site Similarity: N.A. 33.3 N.A. 40 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 6 18 0 0 12 0 6 0 36 0 65 0 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 71 0 6 0 0 0 6 0 0 0 0 0 6 0 % D
% Glu: 6 0 0 0 6 0 0 0 0 0 0 0 0 59 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 6 0 6 6 0 6 % F
% Gly: 0 6 0 0 6 6 6 0 0 83 0 6 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 6 24 0 0 0 6 6 0 0 0 0 0 0 0 % I
% Lys: 0 0 6 0 36 0 0 6 6 0 0 24 0 6 0 % K
% Leu: 6 0 6 6 6 71 0 18 6 0 12 0 6 0 6 % L
% Met: 0 0 0 0 0 0 0 6 0 0 6 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % N
% Pro: 83 0 6 0 0 0 0 0 71 0 0 0 6 0 0 % P
% Gln: 0 6 0 6 30 0 0 0 0 6 0 0 0 6 0 % Q
% Arg: 0 6 0 0 0 6 6 0 0 0 0 59 6 6 0 % R
% Ser: 0 0 0 59 0 12 65 6 6 6 0 0 0 6 6 % S
% Thr: 0 0 6 6 6 0 0 48 0 0 0 6 6 6 59 % T
% Val: 6 6 48 0 12 6 6 6 0 0 42 0 6 6 6 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _