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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM6
All Species:
55.45
Human Site:
Y575
Identified Species:
76.25
UniProt:
Q14566
Number Species:
16
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14566
NP_005906.2
821
92889
Y575
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Chimpanzee
Pan troglodytes
XP_001154613
821
92903
Y575
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Rhesus Macaque
Macaca mulatta
XP_001096068
821
92830
Y575
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Dog
Lupus familis
XP_533338
955
107181
Y709
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Cat
Felis silvestris
Mouse
Mus musculus
P97311
821
92849
Y575
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Rat
Rattus norvegicus
Q62724
507
57351
S293
R
L
R
Q
R
D
G
S
G
I
T
K
S
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510510
779
87819
Y529
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Chicken
Gallus gallus
NP_001006527
916
103481
Y576
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Frog
Xenopus laevis
Q7ZY18
825
93359
Y576
T
L
D
E
V
R
R
Y
L
L
F
A
R
Q
F
Zebra Danio
Brachydanio rerio
XP_002662351
830
93777
Y573
S
L
D
E
I
R
R
Y
L
L
F
A
R
Q
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V461
817
92334
Y567
T
R
E
E
V
L
R
Y
V
T
F
A
R
Q
F
Honey Bee
Apis mellifera
XP_396515
813
91942
Y568
T
Q
S
E
I
I
R
Y
I
N
F
A
K
H
F
Nematode Worm
Caenorhab. elegans
P34647
810
91112
Y578
K
I
D
D
I
K
K
Y
I
A
F
A
R
C
F
Sea Urchin
Strong. purpuratus
XP_783166
823
93674
Y569
S
V
E
D
M
Q
R
Y
L
M
F
A
R
Q
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
M536
I
F
V
K
Y
D
R
M
L
H
G
Q
D
R
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P43299
716
80315
L502
T
P
A
E
N
I
N
L
P
P
A
L
L
S
R
Baker's Yeast
Sacchar. cerevisiae
P53091
1017
112934
Y754
S
A
E
Q
L
R
R
Y
I
K
Y
A
R
T
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.7
83.8
N.A.
95.8
58.9
N.A.
84.7
78.5
82.6
80.9
N.A.
63.5
59.8
54.8
71.5
Protein Similarity:
100
100
100
84.7
N.A.
97.6
60.5
N.A.
89.7
84.8
91.1
89.2
N.A.
79
76.3
71.7
84.2
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
100
100
80
93.3
N.A.
46.6
40
53.3
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
100
100
N.A.
80
66.6
80
100
Percent
Protein Identity:
N.A.
26.4
N.A.
25.8
38.5
N.A.
Protein Similarity:
N.A.
45.6
N.A.
44.7
56.5
N.A.
P-Site Identity:
N.A.
13.3
N.A.
0
46.6
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
0
0
0
0
0
0
6
6
83
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% C
% Asp:
0
0
59
53
0
12
0
0
0
0
0
0
6
0
0
% D
% Glu:
0
0
18
30
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
6
0
0
0
0
0
0
0
0
77
0
0
0
83
% F
% Gly:
0
0
0
0
0
0
6
0
6
0
6
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
6
0
0
0
6
0
% H
% Ile:
6
6
0
0
59
12
0
0
18
6
0
0
0
0
0
% I
% Lys:
6
0
0
6
0
6
6
0
0
6
0
6
6
0
0
% K
% Leu:
0
59
0
0
6
6
0
6
65
53
0
6
6
0
0
% L
% Met:
0
0
0
0
6
0
0
6
0
6
0
0
0
0
0
% M
% Asn:
0
0
0
0
6
0
6
0
0
6
0
0
0
0
0
% N
% Pro:
0
6
0
0
0
0
0
0
6
6
0
0
0
0
0
% P
% Gln:
0
6
0
12
0
6
0
0
0
0
0
6
0
65
0
% Q
% Arg:
6
6
6
0
6
59
83
0
0
0
0
0
77
6
12
% R
% Ser:
59
0
6
0
0
0
0
6
0
0
0
0
6
12
0
% S
% Thr:
24
0
0
0
0
0
0
0
0
6
6
0
0
6
0
% T
% Val:
0
6
6
0
12
0
0
0
6
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
6
% W
% Tyr:
0
0
0
0
6
0
0
83
0
0
6
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _